Many researches conducted in antidepressant therapeutics aimed to obtain a reduction of the delay of action of the drugs. Until now, neither antidepressant per se, nor potentialization strategies (5HT1A agonists), have obtained some significant results. Deep Brain Stimulation (DBS) techniques used in resistant and severe depressive patients have shown a rapid improvement of several patients from the first week of treatment. In that sense, mechanism of action of DBS could represent a model for improving the duration of action of antidepressant.

Comparison of data extracted from clinical trials using antidepressants and those obtained from brain electro stimulation techniques.

The current data do not allow to conclude to a faster action of DBS technique in depression. However, results obtained from randomized control trials will provide some more powerful data.

a better comprehension of the mechanism of action of DBS is crucial for the improvement of the action rapidity of new antidepressants.