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Relation between the first psychotic episode in schizophrenia patients and IL-1β plasma levels – Serbian population study

Published online by Cambridge University Press:  27 August 2024

N. M. Stojanovic ,
S. Tošić Golubović ,
S. Vujić ,
N. Stefanović ,
G. Nikolić ,
A. Todorović ,
A. Vrućinić ,
M. Petković ,
M. Simonović  and
P. Randjelovic
...Show all authors
N. M. Stojanovic*
Affiliation:
1Department of Physiology
S. Tošić Golubović
Affiliation:
2Department of Psychiatry, Faculty of Medicine, University of Niš 3Clinic for Psychiatry, University Clinical Centre
S. Vujić
Affiliation:
4Faculty of Medicine, University of Niš
N. Stefanović
Affiliation:
4Faculty of Medicine, University of Niš
G. Nikolić
Affiliation:
2Department of Psychiatry, Faculty of Medicine, University of Niš 5Centre for mental health, University Clinical Centre
A. Todorović
Affiliation:
6Special Psychiatric Hospital
A. Vrućinić
Affiliation:
7Department of Psychiatry, University Clinical Centre
M. Petković
Affiliation:
1Department of Physiology
M. Simonović
Affiliation:
2Department of Psychiatry, Faculty of Medicine, University of Niš 5Centre for mental health, University Clinical Centre
P. Randjelovic
Affiliation:
1Department of Physiology
T. Jevtović Stoimenov
Affiliation:
8Department of Biochemistry, Faculty of Medicine, University of Niš, Niš, Serbia
*
*Corresponding author.

Abstract

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Introduction

According to immunological theories of schizophrenia prenatal and postnatal exposure to pathogens may contribute to the etiopathogenesis, suggesting that chronically activated immune system cells (macrophages and T lymphocytes) constantly secrete proinflammatory cytokines which affect the development and function of central nervous system.

Objectives

In the present work we aimed to evaluate IL-1β plasma levels in schizophrenic patients during their first psychotic episode and to compare the obtained results to those from healthy subjects.

Methods

Plasma was obtained from 32 drug-naive schizophrenic patients, without history of substance abuse or addiction, immediately after their admission to the medical ward, while the control samples were obtained from 20 healthy volunteers.

Results

Levels of IL-1β were measured using ELISA assay, which measures IL-1β protein in a range from 7.81 to 500 pg/ml. Results revealed that the levels of IL-1β in patients with first psychotic episode were not increased and were below the limit of detection in all studied samples. The same was found in the samples belonging to the control group.

Conclusions

These data contribute to the poll of knowledge and a still unresolved dogma about the etiopathogenesis of schizophrenia since the results obtained by some studies are also questioning this marker. Thus, whether or not an increase of IL-1β is congenital, acquired during the prodromal phase or absent until the time of first psychotic episode has not yet been investigated.

Disclosure of Interest

None Declared

Type
Abstract
Information
European Psychiatry , Volume 67 , Special Issue S1: Abstracts of the 32nd European Congress of Psychiatry , April 2024 , pp. S388
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2024. Published by Cambridge University Press on behalf of European Psychiatric Association
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