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QTc Interval in individuals with schizophrenia receiving antipsychotic as monotherapy or polypharmacy

Published online by Cambridge University Press:  23 March 2020

A. Elliott ,
M. Højlund ,
T.J. Mørk ,
T. Christensen ,
R. Jeppesen ,
N.J. Madsen ,
A.G. Viuff ,
P. Hjorth ,
J.C. Nielsen  and
P. Munk-Jørgensen
A. Elliott
Affiliation:
Aarhus University Hospital, Department of Affective Disorders, Risskov, Denmark Psychiatric Research Academy, Psychiatric Hospital and University of Southern Denmark, Odense, Denmark
M. Højlund
Affiliation:
Aarhus University Hospital, Department of Affective Disorders, Risskov, Denmark Psychiatric Research Academy, Psychiatric Hospital and University of Southern Denmark, Odense, Denmark
T.J. Mørk
Affiliation:
Aarhus University Hospital, Department of Affective Disorders, Risskov, Denmark
T. Christensen
Affiliation:
Aarhus University Hospital, Department of Affective Disorders, Risskov, Denmark
R. Jeppesen
Affiliation:
Aarhus University Hospital, Department of Affective Disorders, Risskov, Denmark
N.J. Madsen
Affiliation:
Aarhus University Hospital, Department of Affective Disorders, Risskov, Denmark
A.G. Viuff
Affiliation:
Regional Psychiatry Services West, Department of Psychiatry, Herning, Denmark
P. Hjorth
Affiliation:
Region of Southern Denmark, Department of psychiatry, Kolding/Vejle, Denmark
J.C. Nielsen
Affiliation:
Aarhus University Hospital, Skejby, Department of Cardiology, Skejby, Denmark
P. Munk-Jørgensen
Affiliation:
Aarhus University Hospital, Department of Affective Disorders, Risskov, Denmark Psychiatric Research Academy, Psychiatric Hospital and University of Southern Denmark, Odense, Denmark

Abstract

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Introduction

Antipsychotics are associated with the polymorphic ventricular tachycardia, Torsade's de pointes, which in worst case can lead to sudden cardiac death. The QTc interval is used as a clinical proxy for Torsade's de pointes. QTc interval is prolonged by monotherapy with antipsychotic, but it is unknown if the QTc interval is prolonged further with antipsychotic polypharmacy.

Objectives

To investigate the associations between QTc interval and antipsychotic mono- and polypharmaceutical treatment, respectively, in schizophrenic patients.

Aims

To learn more about the impact of antipsychotics on the QTc interval.

Methods

An observational cohort study of unselected patients with schizophrenia visiting outpatient facilities in the Region of Central Jutland, Denmark. Patients were enrolled from January 2013 through March 2015 with follow-up until June 2015. Data was collected from clinical interviews and clinical case records.

Results

ECGs were available in 58 patients receiving antipsychotic treatment. We observed no difference in average QTc interval for the whole sample of patients receiving monotherapy or polypharmacy (P = 0.29). However, women presented longer QTc-interval on polypharmacy than on monotherapy (P = 0.01).

Conclusion

We recommend an increased focus on monitoring the QTc interval in woman with schizophrenia receiving antipsychotics as polypharmacy.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
e-Poster walk: Schizophrenia and other psychotic disorders–part 2
Information
European Psychiatry , Volume 41 , Issue S1: Abstract of the 25th European Congress of Psychiatry , April 2017 , pp. S194 - S195
Copyright
Copyright © European Psychiatric Association 2017
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