The association “Ligne de Vie “, created in 2004 propose to help the professional rehabilitation of the ex-drug addicts. She proposes an access to a professional career and a medico-social support during two years.

The aim of this work is to determine the predictive factors for a successful rehabilitation of ex drug addict's persons.

Are included in this study all the subjects having taken contact with the association between September first, 2005 and on June 30, 2006. The criterion of success is the access to a helped employment and its maintenance beyond the one month trial period. This criterion makes it possible to distinguish group 1 responder from group 2 not responder.

49 subjects were included. 25 were responders (group 1), 24 not responders (group 2). The average of age is 38, 56 years, 36,6 years in group 1, and 40,36 in group 2, with 68% of man in the group 1 and 75,5% in Group 2.

There were a statistically significant factors for financial incomes (p=0,002), the absence of psychiatric comorbidities (p = 0,003), dependences prevailing with heroin (p = 0.02) and with the cannabis (p = 0.04). However there were no differences with the other substances, cocaine, ecstasies, and amphetamine. The substitute treatments do not appear determining, 50% in group 1 versus 76% in group 2.

The absence of an acute psychiatric disorder, a poly drug-addiction with opiates and the financial motivation seems to be more determining than the setting under substitution therapy.