BDV is a RNA virus belonging to the family Bornaviridae with a high affinity to the limbic system. BDV interferes with receptors in the CNS, causing changes in neurotransmitter systems, mood and behavioural changes. Higher positivity of BDV has been described in psychiatric patients during the acute course of disorders in comparison with remission and healthy individuals. Substance abuse is associated with behavioural, mood changes, craving, chronical course and high risk of relapses. These characteristics are explained by the influence of drugs and alcohol to opioid and dopamine systems accountable for the reward mechanism. We suppose higher BDV positivity in substance addict patients in the beginning of treatment, lower positivity due to the abstinence period associated with decrease of craving.

Examination of hospitalised patients for substance abuse according to ICD 10 for serum positivity of BDV infection (antigens-Ag, circulating immunocomplexes-CIC) by ELISA on day 1 and day 56 (2 months of abstinence). Evaluation of Questionnaire of Psychic Dependence on day 1 and 56.

We have investigated 21 patients to day. Till December 2006 we suppose there will be minimally 30 investigated patients. We have at disposition results with statistical evaluation in February 2007.

Higher BDV positivity in substance addict patients can be associated with immune changes during abuse. BDV can influence through neurotranmitter systems (dopamine) behaviour of these patients (craving) and be associated with higher risk of relapse. Higher BDV positivity is supposed in the beginning of treatment and associated with more intensive craving.