The symptoms of opium withdrawal usually disappear during 2 weeks. In some patients, after withdrawal, some symptoms of depression such as fatigue, lack of interest, loss of weight, anxiety and loss of energy are observed in which with diagnosis of depression and anxiety medicines the problems remove, and after one period of treatment the patient become healthy.

Rarely the symptoms like yawning, runny nose, and sneezing last, but sometimes they last for a few months. In this study we investigate on 5 patients who still have the acute symptoms of withdrawal even after a year, besides depression symptoms. Anti depression treatment was begun, despite two periods of complete anti depression periods, and even one period of ECT, 2 of the patients still had withdrawal symptoms. In this article, we investigate on the symptoms of prolonged withdrawal syndrome. There are not any similar reports round the world. Researchers believe on gathering more information in order to know this syndrome better.