In our prospective study we analyzed 30 of patienTS with MAJOR DEPRESSIVE DISORDER, treated with cognitive -behavioural therapys: with group therapy only (group I), individual therapy only (group II), or combined individual and group psychotherapy (group III). For 18 months there have been used Beck Depression Inventory (BDI), and Global Assessment of Functioning (GAF) at the beginning, at the end of treatment (after 12 months), and 6 months after treatment. At the beginning of treatment next mean values of whole group were observed: BDI 41,7 ± 8,5, and GAF 49,7 ± 8.7. GAF shoved negative correlation with BDI (-0,62) . After one year of psychotherapy mean value of improvements were: for BDI 37,4 ± 7,5, and for GAF 23,9. GAF still highly correlated with BDI (-62). Six months after last individual and group meeting all parameters were significantly worsen, after 12 months next improvements were observed: group I BDI 44,8 ± 9,3 GAF 20,6 ± 8,0; group II BDI 36,0 ± 14,0 GAF 22,8 ± 11,2 (significantly lower than in group I); group III BDI 33,0 ± 10,8, GAF 28,4 ± 8,3. After 6 months without therapy next worseness were observed: group I: BDI 5,8 ± 3,5, GAF -4,7 ± 2,5; group II: BDI 3,9 ± 1,6, GAF -7,9 ± 7,2; group III: BDI 5,0 ± 2,3, GAF -7,9 ± 5,5.