Modern life, situations of long lasting distress are causing increase of neurosis in our population. A 3.5 years follow-up study, from 2005 to 2009 or 1207 patients show us that agoraphobia (as fear of being in places or situations from which escape might be difficult or embarrassing) is one of the most prevalent anxiety disorders in the field of mental health (89.47%) and also female syndrom. Then we found specific phobia (from death), social phobia, sexual phobia. The primary purpose of this study was to improve our clinical observation that patients with agoraphobia are the most often patients from all anxiety disorders and that is neww expirience from our country. The most frequent neurotic disorder in 3.5 years of examinations in the city of Nish is agoraphobia 89.47% (1080 patients), female SY cause marriege conflict, which comprehends examinations in the world (every 9th person in 1000 in USA and 6th on GB).