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P02-156 - Abnormal Brain Perfusion Among Cocaine Addicts

Published online by Cambridge University Press:  17 April 2020

D.X. Silveira ,
J.G. Santos ,
E. Labigalini ,
A. Baribieri  and
E. Doering-Silveira
D.X. Silveira
Affiliation:
Psychiatry, Federal University of São Paulo, Sao Paulo, Brazil
J.G. Santos
Affiliation:
Neuropharmacology, Faculty of Medicine - Santa Casa, Sao Paulo, Brazil
E. Labigalini
Affiliation:
Psychiatry, Federal University of São Paulo, Sao Paulo, Brazil
A. Baribieri
Affiliation:
Radiology, Federal University of São Paulo, Sao Paulo, Brazil
E. Doering-Silveira
Affiliation:
Neuropsychology, Federal University of São Paulo, Sao Paulo, Brazil

Abstract

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Introduction

Cocaine use is related to several cardiovascular conditions. Vasoconstriction seems to be particularly harmful to the brain.

Objective

To evaluate the relationship between the pattern of cocaine use and cerebral perfusion among cocaine addicts.

Method

A sample of 30 cocaine addicts was studied using 99 m-Tc-HMPAO SPECT (single photon emission computed tomography with injection of 99 m-Tc-hexametilpropilenoamina-oxime). Their cerebral perfusion pattern was then compared with their pattern of cocaine use.

Results

Eighty percent of the sample presented some degree of impairment in brain perfusion, either focal or diffuse. There was no difference between sniffers and crack smokers regarding their perfusion patterns. No relationship could be established between the severity of SPECT abnormalities and the amount of drug consumption or the duration of abstinence. However, duration of cocaine use did correlate with the severity of cerebral perfusion (Spearman correlation coefficient: r = 0.45, p < 0.05).

Conclusion

This study documents the high frequency of cerebral functional impairment in cocaine addicts and establishes the relationship between duration of cocaine exposure and severity of perfusion abnormalities.

Type
Neuroimaging
Information
European Psychiatry , Volume 25 , Issue S1: 18th European Congress of Psychiatry. February 27, March 2, 2010 - Munich, Germany , 2010 , 25-E770
Copyright
Copyright © European Psychiatric Association 2010
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