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P0172 - Some particularities of depression in diabetic patients

Published online by Cambridge University Press:  16 April 2020

A. Baloescu ,
G. Grigorescu  and
M.D. Gheorghe
A. Baloescu
Affiliation:
Euroclinic Hospital, Bucharest, Romania
G. Grigorescu
Affiliation:
Central Military Hospital, Bucharest, Romania
M.D. Gheorghe
Affiliation:
Euroclinic Hospital, Bucharest, Romania

Abstract

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The presence of diabetes doubles the odds of comorbid depression. In patients with preexisting diabetes, depression is an independent risk factor for coronary disease and appears to accelerate the presentation of coronary heart disease. Concurrent depression is associated with a decrease in metabolic control of diabetes mellitus, poor adherence to medication and diet regimens, a reduction in quality of life and an increase in health care expenditures.

Objective:

To diagnose and treat the depression illness in diabetic patients.

Methods:

A sample of 30 diabetic patients (15 women, 15 men), mean age 59,6 years was assessed for depression - ICD 10 criteria. HAM-D (Hamilton for depression scale), CGI-S (Clinical global impression –severity) and CGI-I (Clinical global impression –improvement) were performed at baseline, 7, 14, 21, 28 and 42 days. Patients received antidepressive medication: tianeptine 37,5 mg/day or venlafaxine 75-150 mg/day.

Results:

Mean score HAM D at baseline was 21.4. The reassessment after 7, 14, 21, 28 and 42 days revealed significant decrease of depressive symptomathology after 4 weeks of medication (HAM D was 15.4). After 42 days the mean score HAM-D was 9,5. CGI-S at baseline was 4.5 and on 42 day 1.8. Mean blood glucose was evaluated from 215,5 mg/dl at inclusion and 142,3mg/dl on day 42.

Conclusions:

1) Successful treatment of depression is associated with improvements in glycemic control. 2) Improvements in mood increase the functioning and quality of life. 3) Further studies are important to demonstrate the role of maintenance antidepressant treatment for the prevention of recurrence.

Type
Poster Session II: Depression
Information
European Psychiatry , Volume 23 , Issue S2: 16th AEP Congress - Abstract book - 16th AEP Congress , April 2008 , pp. S242 - S243
Copyright
Copyright © European Psychiatric Association 2008
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