Kashmir has observed increase in number of Substance dependence patients due to various factors like easy availability of drugs, drugs smuggled across border, unemployment but most importantly present disturbed conditions for last two decades. Drug use appears to have an important role in vulnerability to development of psychiatric disorders and vice versa. Substance dependence Patients with comorbid psychiatric disorders are difficult to treat. A methodical, staged screening and assessment can ease the diagnostic challenge of distinguishing the symptoms of psychiatric disorders from manifestations of substance intoxication and withdrawal. This study was carried out on total of 300 substance dependence patients who were screened for psychiatric disorders by DSM IV based MINI Plus interview. The statistical analysis of the data was done by using Chi-square test χ2 test. The study revealed that 58% (n=174) had psychiatric comorbidity, Most of these patients with dual diagnosis of psychiatric Disorders and substance dependence 87.35% (n=152) belonged to < 38 year age group. Majority were males 95.40% (n=166) and unmarried/ divorced 64.36% (n=112), Illiterate patients out numbered educated 45.97% (n=80). Most of the patients in this study were unemployed 41.37% (n=72). Peer group pressure / curiosity (54.02%) were the most common precipitating factor followed by the traumatic stress (12.64%). Most common substances used by these dually diagnosed patients were cannabis (37.93%) followed by combination of Opioids & benzodiazepines (32.75%). Commonly associated psychiatric disorders were psychotic disorders (33.90%), mood disorders (32.18%) & post traumatic stress disorders (PTSD) in 11.49 %.