To study influence of gender specific of formation of heroin addiction (HA) on prognosis and therapy in adolescents.

We have examined 140 patients with HA (15-20 years), among these we have distinguished 4 groups with various gender types (GT). Control – healthy adolescents.

clinical and sexological scales, W. Stephenson's Q-sorting scale, cluster analysis of gender parameters (biological sex, valuable orientations, sexual experience, and social status. We have studied efficacy of paroxetine at week 2, 4 of application at dose 20 mg a day.

In cluster analysis of gender parameters we have distinguished 4 masculine and 4 feminine types of formation of HA. Masculine types of HA: 1. Gender-dominant type (GDT). 2. Gender-independent type (GIDT). 3. Gender-partner type (GPT). 4. Gender-integrating type (GIT). Feminine types of HA: 1. Gender-repressive type (GRT). 2. Gender-independent type (GIDT). 3. Gender-partner type (GPT). 4. Gender-utilitarian type (GUT). Therapy: Efficacy of the paroxetine is maximal from post-withdrawal period in masculine GPT and GIDT. Number of patients with 50% reduction of scores according to scales HAM-А and HAM-D(17) was at visit 3 - 62,8% (in group of comparison – 31,7) and 32,6% (27,3%), at visit 4 – 81,3% (59,1) and 69,8% (54,2%), respectively. Addicted boys have more favorable prognosis than girls. Prognostically favorable for boys are GIDT and GIT, in co-dependent girls - GRT. Adverse type in boys is GDT and in girls – GUT.

Formation of HA in adolescents has gender-associated types with different prognoses and therapy.