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OPUS -trial: Five-year Follow-up of a RCT of Specialized Treatment for Patients with First Episode Psychosis

Published online by Cambridge University Press:  16 April 2020

M. Nordentoft ,
M. Bertelsen ,
P. Jeppesen ,
L. Petersen ,
A. Thorup ,
P. Le Quack ,
G. Krarup  and
P. Jørgensen
M. Nordentoft
Affiliation:
Psychiatric Centre Bispebjerg, Copenhagen University Hospital, Copenhagen, Denmark
M. Bertelsen
Affiliation:
Psychiatric Centre Bispebjerg, Copenhagen University Hospital, Copenhagen, Denmark
P. Jeppesen
Affiliation:
Psychiatric Centre Bispebjerg, Copenhagen University Hospital, Copenhagen, Denmark
L. Petersen
Affiliation:
Psychiatric Centre Bispebjerg, Copenhagen University Hospital, Copenhagen, Denmark
A. Thorup
Affiliation:
Psychiatric Centre Bispebjerg, Copenhagen University Hospital, Copenhagen, Denmark
P. Le Quack
Affiliation:
Psychiatric University Hospital Risskov, Aarhus University, Aarhus, Denmark
G. Krarup
Affiliation:
Psychiatric University Hospital Risskov, Aarhus University, Aarhus, Denmark
P. Jørgensen
Affiliation:
Psychiatric University Hospital Risskov, Aarhus University, Copenhagen, Denmark

Abstract

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Objective:

To determine long term effects of intensive early intervention programme (OPUS)for first episode psychotic patients.

Design:

RCT of two years of intensive early-intervention programme versus standard treatment. Follow-up was two and five years.

Patients:

547 first-episode psychotic patients were included and interviewed after two years (N=369) and five years (N=301). Registerbased information was available for all patients.

Interventions:

The intensive early intervention programme OPUS consisted of ACT with family involvement and social skills training.

Results:

At five-year follow-up, the positive effect of the OPUS treatment seen after two years had equalized between treatment groups. A significantly smaller percentage of patients from the experimental group were living in supported housing (4% vs. 10%, OR 2.3, 95% CI 1.1 to 4.8, P =0.02) and were hospitalized fewer days (mean days 149 vs. 193, mean difference 44, 95% CI 0.15 to 88,12 P= 0.05) during the five-year period.

Conclusions:

The OPUS treatment improved clinical outcome after two years, but the effects were not sustainable up to five years after. A difference on supported housing and use of bed days were found after five years in favour of the OPUS treatment.

Type
S21-01
Information
European Psychiatry , Volume 24 , Issue S1: 17th EPA Congress - Lisbon, Portugal, January 2009, Abstract book , January 2009 , 24-E111
Copyright
Copyright © European Psychiatric Association 2009

References

Reference:

Bertelsen, , et al.The OPUS-trial; A five-years follow-up. Arch Gen Psych 2008; 65: 762–771CrossRefGoogle Scholar
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