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Neuropsychiatric Manifestations of Tuberous Sclerosis in a young adult male in a Psychiatry Hospital in Botswana: a case report

Published online by Cambridge University Press:  27 August 2024

W. T. Chabalala ,
K. Bojosi ,
T. Maphane  and
A. Olashore
W. T. Chabalala*
Affiliation:
1Department of Psychiatry, University of Botswana 2Department of Psychiatry, Sbrana Psychiatry Hospital, Gaborone, Botswana
K. Bojosi
Affiliation:
1Department of Psychiatry, University of Botswana 2Department of Psychiatry, Sbrana Psychiatry Hospital, Gaborone, Botswana
T. Maphane
Affiliation:
1Department of Psychiatry, University of Botswana 2Department of Psychiatry, Sbrana Psychiatry Hospital, Gaborone, Botswana
A. Olashore
Affiliation:
1Department of Psychiatry, University of Botswana 2Department of Psychiatry, Sbrana Psychiatry Hospital, Gaborone, Botswana
*
*Corresponding author.

Abstract

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Introduction

Tuberous sclerosis complex (TSC) is a disorder that affects multiple systems and was first described in 1880. Its symptoms include seizures, intellectual disability, and adenoma sebaceum. TSC is caused by mutations in the TSC1 and TSC2 genes and is inherited in an autosomal dominant manner.

Objectives

This report highlights a case of a patient with an unusual psychological presentation evaluated in a psychiatric hospital.

Methods

The patient presented with psychotic features and abnormal behavior. A physical examination showed neurocutaneous lesions. After assessment a diagnosis of Tuberous sclerosis complex was confirmed through MRI Brain and genetic testing. Some of his relatives also showed similar neuropsychiatric symptoms.

Results

Tuberous sclerosis complex is diagnosed based on TSC Clinical Consensus Group guidelines of 2012. Our patient fulfilled 4 of the major criteria and genetic testing also yielded a pathogenic variant. A TAND checklist (TSC-Associated Neuropsychiatric Disorders) is used to guide clinicians on areas to prioritize when managing TSC patients.

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Conclusions

Given that psychiatry may be the first contact for TSC patients, especially in low-resource settings. Patients referred to psychiatry, therefore, need to be thoroughly examined to exclude neuropsychiatric disorders, and a multidisciplinary team approach is vital in investigating and managing these cases.

Disclosure of Interest

None Declared

Type
Abstract
Information
European Psychiatry , Volume 67 , Special Issue S1: Abstracts of the 32nd European Congress of Psychiatry , April 2024 , pp. S495 - S496
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2024. Published by Cambridge University Press on behalf of European Psychiatric Association
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