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Mania and alzheimer disease, review and case report

Published online by Cambridge University Press:  27 August 2024

M. Garcia Moreno*
Affiliation:
1Psychiatry, Hospital Universitario Puerta de Hierro Majadahonda
A. De Cos Milas
Affiliation:
2Psychiatry, Hospital Universitario de Móstoles, Madrid, Spain
L. Beatobe Carreño
Affiliation:
2Psychiatry, Hospital Universitario de Móstoles, Madrid, Spain
P. Del Sol Calderón
Affiliation:
1Psychiatry, Hospital Universitario Puerta de Hierro Majadahonda
A. Izquierdo de la Puente
Affiliation:
1Psychiatry, Hospital Universitario Puerta de Hierro Majadahonda
*
*Corresponding author.

Abstract

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Introduction

There are numerous organic causes that can be related to affective symptoms such as neurological, metabolic, infectious and pharmacological. Neurological conditions associated to affective symptoms include vascular lesions, tumors, infections, seizures and dementia. Within cognitive impairment conditions, depressive symptoms are more frequent in vascular dementia and Alzheimer disease, and behavioral or manic symptoms in frontotemporal dementia although we cannot rule out less common associations.

Objectives

To review about organic mania due to dementia

Methods

We carry out a literature review about organic mania accompanied by a clinical description of one patient with manic symptoms and cognitive impairment.

Results

A 80-year-old male was admitted to the short-term hospitalization unit from the emergency department due to maniform symptoms. He had believed for weeks that he was millionaire and capable to cure all the diseases in the world, reason for which he had given away many of his belongings and had tried to register the patent for his invent. He also had future plans to invest all the money he earned from the patent in the construction of roads in Latin America. He had not previous history of mental illness. Neurological study concluded a diagnosis of Alzheimer disease. It was treated as a manic episode with a mood stabilizer and antipsychotic, with partial resolution of the condition.

Conclusions

It is common to find depressive symptoms in cognitive disorders. Although manic symptoms are much more frequent in frontotemporal dementia or other organic disorders, we can also find them in patients with Alzheimer disease. Since there is no specific curative treatment for this disease, concomitant psychopharmacological treatment is recommended if manic symptoms appear.

Disclosure of Interest

None Declared

Type
Abstract
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2024. Published by Cambridge University Press on behalf of European Psychiatric Association
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