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Long-term rates of remission and late psychotic transition of individuals at risk for psychosis

Published online by Cambridge University Press:  23 March 2020

K. Beck ,
C. Andreou ,
E. Studerus ,
L. Egloff ,
U. Heitz ,
S. Menghini-Müller ,
S. Ittig ,
L. Leanza ,
M. Uttinger  and
A. Simon
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K. Beck
Affiliation:
University of Basel Psychiatric Hospital, Center for Gender Research and Early Detection, Basel, Switzerland
C. Andreou
Affiliation:
University of Basel Psychiatric Hospital, Center for Gender Research and Early Detection, Basel, Switzerland
E. Studerus
Affiliation:
University of Basel Psychiatric Hospital, Center for Gender Research and Early Detection, Basel, Switzerland
L. Egloff
Affiliation:
University of Basel Psychiatric Hospital, Center for Gender Research and Early Detection, Basel, Switzerland
U. Heitz
Affiliation:
University of Basel Psychiatric Hospital, Center for Gender Research and Early Detection, Basel, Switzerland
S. Menghini-Müller
Affiliation:
University of Basel Psychiatric Hospital, Center for Gender Research and Early Detection, Basel, Switzerland
S. Ittig
Affiliation:
University of Basel Psychiatric Hospital, Center for Gender Research and Early Detection, Basel, Switzerland
L. Leanza
Affiliation:
University of Basel Psychiatric Hospital, Center for Gender Research and Early Detection, Basel, Switzerland
M. Uttinger
Affiliation:
Hospitals of Solothurn, Psychiatric Services of Solothurn, Solothurn/Olten, Switzerland
A. Simon
Affiliation:
Specialized Early Psychosis Outpatient Service for Adolescents and Young Adults, Department of Psychiatry, Bruderholz, Switzerland
S. Borgwardt
Affiliation:
University of Basel Psychiatric Hospital, Department of Psychiatry, Basel, Switzerland
A. Riecher-Rössler
Affiliation:
University of Basel Psychiatric Hospital, Center for Gender Research and Early Detection, Basel, Switzerland

Abstract

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Introduction

In the growing research field of early psychosis detection in patients with an at risk mental state (ARMS), most studies focus on the transition to frank psychosis. However, the majority of ARMS patients do not go on to develop frank psychosis and reported transition rates are declining. Little is known about the long-term outcome of these non-transitioned patients (ARMS-NT).

Objectives

To investigate in preliminary analyses the long-term outcome of ARMS-NT patients with respect to persistence of ARMS signs and symptoms and the rates of late psychotic transition.

Methods

The ongoing study “FePsy-BHS-NT” follows up ARMS-NT without transition during at least the first two years for up to 15 years after their initial assessment. ARMS status is ascertained with the Basel Screening Instrument for Psychosis (BSIP). ARMS remission is defined as the absence of attenuated psychotic symptoms or brief limited intermittent psychotic symptoms for at least 12 consecutive months.

Results

In this preliminary sample of 51 ARMS-NT, the majority of patients (70.6%) have remitted from their at risk mental state, 13.7% remain at risk and 15.7% have made a late psychotic transition during the course of long-term follow up (median = 5.75, range 4–11 years after initial assessment).

Conclusions

The considerable rates of ARMS persistence and late psychotic transition indicate that longer follow-up durations than commonly recommended should be contemplated in ARMS patients. Potential predictors of favorable long-term clinical outcome, as well as psychosocial, neurocognitive and other outcomes of ARMS-NT patients will be further evaluated in the present study.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
e-Poster walk: Schizophrenia and other psychotic disorders–part 1
Information
European Psychiatry , Volume 41 , Issue S1: Abstract of the 25th European Congress of Psychiatry , April 2017 , pp. S186
Copyright
Copyright © European Psychiatric Association 2017
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