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Interaction Between Parental Psychosis and Delays On Early Motor Developmental Milestones in Schizophrenia – the Northern Finland Birth Cohort 1966 Study

Published online by Cambridge University Press:  15 April 2020

E. Keskinen ,
A. Marttila ,
R. Marttila ,
P.B. Jones ,
G.K. Murray ,
K. Moilanen ,
H. Koivumaa-Honkanen ,
P. Mäki ,
M. Isohanni  and
E. Jääskeläinen
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E. Keskinen
Affiliation:
Department of Psychiatry, University of Oulu, Oulu, Finland
A. Marttila
Affiliation:
Department of Psychiatry, University of Oulu, Oulu, Finland
R. Marttila
Affiliation:
Department of Psychiatry, University of Oulu, Oulu, Finland
P.B. Jones
Affiliation:
Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
G.K. Murray
Affiliation:
Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
K. Moilanen
Affiliation:
Department of Psychiatry, University of Oulu, Oulu, Finland
H. Koivumaa-Honkanen
Affiliation:
Department of Psychiatry, University of Eastern Finfland, Kuopio, Finland
P. Mäki
Affiliation:
Department of Psychiatry, University of Oulu, Oulu, Finland
M. Isohanni
Affiliation:
Department of Psychiatry, University of Oulu, Oulu, Finland
E. Jääskeläinen
Affiliation:
Department of Psychiatry, University of Oulu, Oulu, Finland
J. Miettunen
Affiliation:
Department of Psychiatry, University of Oulu, Oulu, Finland

Abstract

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Background

Our aim was to investigate how age of achieving early motor developmental milestones differ among subjects with and without a history of parental psychosis and whether parental psychosis may alter the effects of the age of achievement on the risk of schizophrenia.

Methods

The study sample comprised 10,307 individuals from the prospective Northern Finland Birth Cohort 1966. A total of 139 (1.3%) cohort members suffered from schizophrenia by the age of 46 years. Out of them 19 (13.7%) had a parent with a history of psychosis, while among the non-psychotic cohort members this figure was 524 (5.2%).

Results

Out of eight different motor milestones investigated, parental psychosis associated (p>0.05) with later learning of holding head up, grabbing object, and walking without support. In the parental psychosis group, significant risk factors for schizophrenia included later learning of holding head up and touching thumb with index finger. In the non-parental psychosis group risk estimates were lower and statistical significant milestones were different i.e. turning over, sitting without support, standing up, standing and walking without support. Interactions between parental psychosis and touching thumb with index finger and walking without support was found.

Conclusions

Although parental psychosis associated with delays in motor milestones in the first year of life, it does not explain the association between late achievement of motor milestones and later risk for schizophrenia

Type
Article: 0273
Information
European Psychiatry , Volume 30 , Issue S1: Abstracts of the 23rd European Congress of Psychiatry , March 2015 , pp. 1
Copyright
Copyright © European Psychiatric Association 2015
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