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Global arginine bioavailability ratio is decreased in patients with major depressive disorder

Published online by Cambridge University Press:  23 March 2020

T. Ali-Sisto ,
T. Tolmunen ,
H. Viinamäki ,
P. Mäntyselkä ,
V. Velagapudi  and
L. Soili
T. Ali-Sisto
Affiliation:
University of Eastern Finland, Institute of Clinical Medicine, Kuopio, Finland
T. Tolmunen
Affiliation:
University of Eastern Finland, Institute of Clinical Medicine, Kuopio, Finland Kuopio University Hospital, Department of psychiatry, Kuopio, Finland
H. Viinamäki
Affiliation:
University of Eastern Finland, Institute of Clinical Medicine, Kuopio, Finland Kuopio University Hospital, Department of psychiatry, Kuopio, Finland
P. Mäntyselkä
Affiliation:
University of Eastern Finland, Primary Health Care Unit, Kuopio, Finland Kuopio University Hospital, Primary Health Care Unit, Kuopio, Finland
V. Velagapudi
Affiliation:
Institute for Molecular Medicine Finland, Metabolomics unit, Helsinki, Finland
L. Soili
Affiliation:
University of Eastern Finland, Institute of Clinical Medicine, Kuopio, Finland Kuopio University Hospital, Department of psychiatry, Kuopio, Finland

Abstract

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Introduction

The global arginine bioavailability ratio (GABR) is used to estimate arginine supply. Arginine is precursor to nitric oxide (NO) that has been suggested to play a role in major depressive disorder (MDD). NO also participates in neuronal, inflammatory and cardioprotective functions.

Objectives

To compare GABR between:

– D patients and non-depressed controls;

– remitted and non-remitted MDD patients;

– baseline and follow-up within remitted and non-remitted MDD groups.

Aims

To investigate the role of NO production in MDD.

Methods

The sample comprised 99 MDD patients and 253 non-depressed controls (Beck Depression Inventory scores < 10) aged 20–71 years. Altogether, 78 patients returned for the follow-up; 33 were remitted and 45 non-remitted. GABR was calculated from serum levels of arginine, citrulline and ornithine, which were analysed using ultra-performance liquid chromatography. Differences between the study groups were examined using logistic regression adjusted for age, gender, smoking, alcohol use, physical exercise and glycated haemoglobin. The follow-up regression analyses were adjusted for age, gender and physical exercise.

Results

Lowered GABR was associated with belonging to the MDD group (OR 0.13, 95% CI 0.03–0.50). Exclusion of participants using anti-depressants that were associated with measured metabolites did not change the results. Over the follow-up period, the remitted and non-remitted groups both showed an increase in GABR (Z = –.53, P < 0.001 and Z = –3.00, P = 0.003, respectively).

Conclusions

Decreased GABR may characterise MDD. This could affect neuronal, immunological and cardioprotective functions of NO.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
e-Poster viewing: Cultural psychiatry
Information
European Psychiatry , Volume 41 , Issue S1: Abstract of the 25th European Congress of Psychiatry , April 2017 , pp. S521
Copyright
Copyright © European Psychiatric Association 2017
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