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Efficacy of modified electroconvulsive therapy combined with antipsychotic medication in treatment-refractory schizophrenia

Published online by Cambridge University Press:  16 April 2020

Z.H. Yi ,
Q.H. Xu ,
G.H. Sheng ,
GJ. Wu ,
H.Y. Deng  and
L.P. Zhu
Z.H. Yi
Affiliation:
Shanghai Mental Health Center, Shanghai, China
Q.H. Xu
Affiliation:
Shanghai Mental Health Center, Shanghai, China
G.H. Sheng
Affiliation:
Shanghai Mental Health Center, Shanghai, China
GJ. Wu
Affiliation:
Shanghai Mental Health Center, Shanghai, China
H.Y. Deng
Affiliation:
Shanghai Mental Health Center, Shanghai, China
L.P. Zhu
Affiliation:
Shanghai Mental Health Center, Shanghai, China

Abstract

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Objectives:

To examine the Efficacy and side effects of modified electroconvulsive therapy (MECT) combined with antipsychotic medication in treatment-refractory schizophrenia(TRS).

Methods:

the 39 patients with TRS who had received antipsychotic medication were assigned to receive MECT, and the Positive and Negtive Syndrome Scale (PANSS) ,Treatment Emergent Symptoms Scale (TESS) and Wechsler Memory Scale were used to measure therapeutic efficacy ,side effects and memory function.

Results:

The PANSS scores decreased significantly at 1,4,12 weeks after MECT (P<0.01), and the efficacy ratio of MECT at 1,4,12 weeks treatment was 5%,26%,23% respectively. No significant difference was found on the scores of TESS between before and after endpoint treatment of MECT. The WMS scores decreased significantly at 1 day after endpoint of MECT, but there was no significant difference between before and after 1,2 weeks of endpoint treatment of MECT.

Conclusion:

MECT was effective in TRS case, and it had little side effects and a little effect on memory temporarily.

Type
Poster Session 2: ECT
Information
European Psychiatry , Volume 22 , Issue S1: 15th AEP Congress - Abstract book - 15th AEP Congress , March 2007 , pp. S266
Copyright
Copyright © European Psychiatric Association 2007
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