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Childhood trauma and cortisol awakening response in eating disorders: A dose-dependent trauma effect

Published online by Cambridge University Press:  23 March 2020

F. Monaco ,
A.M. Monteleone ,
F. Pellegrino ,
F. De Riso ,
G. Patriciello ,
M. Cimino ,
M. Calvanese ,
U. Volpe  and
P. Monteleone
F. Monaco*
Affiliation:
University of Naples SUN, Department of Psychiatry, Naples, Italy
A.M. Monteleone
Affiliation:
University of Naples SUN, Department of Psychiatry, Naples, Italy
F. Pellegrino
Affiliation:
University of Naples SUN, Department of Psychiatry, Naples, Italy
F. De Riso
Affiliation:
University of Naples SUN, Department of Psychiatry, Naples, Italy
G. Patriciello
Affiliation:
University of Naples SUN, Department of Psychiatry, Naples, Italy
M. Cimino
Affiliation:
University of Naples SUN, Department of Psychiatry, Naples, Italy
M. Calvanese
Affiliation:
University of Naples SUN, Department of Psychiatry, Naples, Italy
U. Volpe
Affiliation:
University of Naples SUN, Department of Psychiatry, Naples, Italy
P. Monteleone
Affiliation:
University of Salerno, Department of Medicine and Surgery- Neuroscience Section, Salerno, Italy
*
*Corresponding author.

Abstract

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Introduction

A role for the hypothalamus-pituitary-adrenal (HPA) axis has been suggested in the pathophysiology of anorexia nervosa (AN) and bulimia nervosa (BN), and childhood trauma experiences have been detected frequently in patients with AN and BN. Since trauma exposure in the childhood may persistently affect HPA axis functioning, we explored HPA axis activity in AN and BN patients with and without childhood trauma history.

Objectives and aims

We aimed to examine possible associations between childhood traumatic experiences and HPA axis functioning, as assessed by the cortisol awakening response (CAR), in adult patients with AN or BN as compared to adult healthy controls.

Methods

Saliva samples were collected by 41 patients with symptomatic AN, 32 with symptomatic BN and 45 healthy controls at wakening and after 15, 30 and 60 min. They filled in the Childhood Trauma Questionnaire (CTQ), which assesses five specific types of childhood trauma.

Results

As compared to the control group, the no-maltreated AN patient group exhibited an enhanced CAR whereas the no-maltreated BN patient group showed a similar CAR. On the contrary, both AN and BN patients with a positive history of childhood maltreatment exhibited statistically significant blunted CAR as compared to no-maltreated patients. Moreover, in maltreated ED patients the CAR tended to decrease when the number of trauma types increased.

Discussion

Present findings confirm a dysregulation of the HPA axis activity in symptomatic patients with AN and BN and suggest a dose-dependent effect of childhood adverse experiences on the CAR of adult ED patients.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
EW211
Information
European Psychiatry , Volume 33 , Issue S1: Abstracts of the 24th European Congress of Psychiatry , March 2016 , pp. S165
Copyright
Copyright © European Psychiatric Association 2016
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