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Cardiovascular and Respiratory Comorbidities in Patients with Bipolar Disorder: A Systematic Review

Published online by Cambridge University Press:  16 April 2020

J.M. Montes ,
J. Mostaza ,
F. Rico-Villademoros ,
J. Saiz-Ruiz ,
J. Bobes  and
E. Vieta
J.M. Montes
Affiliation:
Department of Psychiatry, Hospital del Sureste, University of Alcalá, CIBERSAM, Madrid, Spain
J. Mostaza
Affiliation:
Department of Internal Medicine, Hospital Carlos III, University of Alcalá, CIBERSAM, Madrid, Spain
F. Rico-Villademoros
Affiliation:
Universidad de Alcalá de Henares, Hospital Ramón y Cajal, University of Alcalá, CIBERSAM, Madrid, Spain
J. Saiz-Ruiz
Affiliation:
Department of Psychiatry, Hospital Ramón y Cajal, University of Alcalá, CIBERSAM, Madrid, Spain
J. Bobes
Affiliation:
Department of Medicine, University of Oviedo, CIBERSAM, Oviedo, Spain
E. Vieta
Affiliation:
Hospital Clinic, University of Barcelona, CIBERSAM, Barcelona, Spain

Abstract

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Objective:

To synthesize the available knowledge on cardiovascular and respiratory comorbidities in patients with bipolar disorder (BD).

Methods:

Relevant studies were identified by a MEDLINE search from 1966 to January 2008, and supplemented by a manual review of reference lists of the articles identified and previous review articles. When available, priority was given to comparative studies.

Results:

We identified 21 studies, 15 (71%) comparative. As compared to the general population, two studies reported higher point-prevalence rates of hypertension (28-60.8% vs 11.9-43%), two studies lower point-prevalence rates (10.4-34.8% vs 14.9-36.8%), one study a higher lifetime-prevalence rate (28.7% vs 14.8%), and one study a significantly increased incidence rate ratio (1.24 females and 1.34 for males). In addition, two studies reported higher point-prevalence rates of hypertension than in medical samples (4.6-18.1% vs 2.2-9.2%) and one study reported a higher risk than in patients with schizophrenia (OR 1.13, 95%CI 1.01-1.26). Point-prevalence rate of stroke was not different than in the general population (n=1, 1.7 vs 2.1, p=0.063); four studies evaluating the risk of stroke as compared to clinical samples provide contradictory results. Point-prevalence rates (n=2, 15.9-17% vs 8.3-10%) and lifetime-prevalence rate (n=1, 16.7% vs 9.7%) of asthma were higher than in the general population. Point-prevalence rates of COPD were also higher than in the general population (n=1, 10.6% vs 9.4%) and in clinical samples (n=3, 1-12.9% vs 0.6-3.6%).

Conclusion:

BD seems to be associated with increased rates of hypertension, asthma and COPD. Available data do not support the association between BD and stroke.

Type
P01-202
Information
European Psychiatry , Volume 24 , Issue S1: 17th EPA Congress - Lisbon, Portugal, January 2009, Abstract book , January 2009 , 24-E590
Copyright
Copyright © European Psychiatric Association 2009
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