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Brain structure changes associated with depression outcome in adolescents bullied throughout adolescence

Published online by Cambridge University Press:  19 July 2023

M.-L. Paillere-Martinot ,
A. Briffod ,
P.-A. Beaudoin ,
O. Hassani ,
J.-L. Martinot  and
E. Artiges
M.-L. Paillere-Martinot*
Affiliation:
INSERM U1299 “Developmental trajectories & psychiatry”, Université Paris-Saclay, Ecole Normale Supérieure Paris-Saclay - CNRS - Centre Borelli
A. Briffod
Affiliation:
Ecole CentraleSupélec, Université Paris-Saclay, CentraleSupélec, Gif-sur-Yvette, France
P.-A. Beaudoin
Affiliation:
Ecole CentraleSupélec, Université Paris-Saclay, CentraleSupélec, Gif-sur-Yvette, France
O. Hassani
Affiliation:
Ecole CentraleSupélec, Université Paris-Saclay, CentraleSupélec, Gif-sur-Yvette, France
J.-L. Martinot
Affiliation:
INSERM U1299 “Developmental trajectories & psychiatry”, Université Paris-Saclay, Ecole Normale Supérieure Paris-Saclay - CNRS - Centre Borelli
E. Artiges
Affiliation:
INSERM U1299 “Developmental trajectories & psychiatry”, Université Paris-Saclay, Ecole Normale Supérieure Paris-Saclay - CNRS - Centre Borelli
*
*Corresponding author.

Abstract

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Introduction

Being bullied in adolescence has been associated with developing depressive symptoms in adulthood.

Objectives

We sought to describe the trajectories of peer victimization across adolescence and their relationships with grey matter volumes and depression outcomes in young adulthood.

Methods

Community adolescents from the IMAGEN database (n = 724) with both peer victimization and neuroimaging data were included. A longitudinal clusterization method (normal mixture model) was used to analyze the bullying scores at baseline (age 14), and at follow-ups at age 16, 18 and 22. Relations between clusters and brain volumes or depression diagnosis were examined using logistic and linear multivariate regression models.

Results

Three victimization trajectories were observed. A first trajectory included participants who were never bullied and had no depression outcome, a second trajectory identified participants who were bullied at age 14 and 16 only, and had no depression outcome, and finally, a third trajectory of continuous bullying throughout adolescence to young adulthood (age 22) that was significantly associated with depression outcomes (r=0.87, p=0.0004). In addition, the continuously bullied participants displayed larger volumes of bilateral hippocampus, posterior cingulate cortex and right putamen at age 22.

Conclusions

These data confirm that chronic peer victimization throughout adolescence is associated with brain structure changes and might increase vulnerability to depressive disorders. They highlight the need for preventive school interventions in early adolescents.

Disclosure of Interest

None Declared

Type
Abstract
Information
European Psychiatry , Volume 66 , Special Issue S1: Abstracts of the 31st European Congress of Psychiatry , March 2023 , pp. S105
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of the European Psychiatric Association
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