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Association between adult adhd and generalised joint hypermobility, with and without systemic manifestations: A case-control study

Published online by Cambridge University Press:  13 August 2021

M. Glans ,
S. Bejerot ,
M. Humble ,
M. Elwin  and
N. Thelin
M. Glans*
Affiliation:
Faculty Of Medicine And Health, Örebro University, Örebro, Sweden
S. Bejerot
Affiliation:
Faculty Of Medicine And Health, Örebro University, Örebro, Sweden
M. Humble
Affiliation:
Faculty Of Medicine And Health, Örebro University, Örebro, Sweden
M. Elwin
Affiliation:
Faculty Of Medicine And Health, Örebro University, Örebro, Sweden
N. Thelin
Affiliation:
Division Of Psychiatry, Linköping University Hospital, Linköping, Sweden
*
*Corresponding author.

Abstract

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Introduction

There is growing evidence that generalised joint hypermobility (GJH) is associated with several psychiatric conditions. There are no previous studies on adult ADHD.

Objectives

To evaluate, in a large Swedish sample, if generalised joint hypermobility and adult ADHD are associated.

Methods

431 adults with ADHD and 417 controls were included. GJH was assessed by the Beighton Score, a physical examination, and the 5PQ, a self-report screening tool. Exploratively, reported musculoskeletal symptoms and abnormal skin manifestations suggestive of symptomatic GJH (e.g. Ehlers-Danlos syndrome), were assessed to differentiate this group from the general GJH group. Logistic regressions determined the influence of an ADHD diagnosis and known covariates (age, sex and ethnicity) on GJH and symptomatic GJH respectively.

Results

ADHD was associated to GJH, as defined by the Beighton Score and the 5PQ, with adjusted odds ratios of 4.65 (CI 95% 3.01-7.18, p<.005) and 1.86 (CI 95% 1.39-2.48, p<.005), respectively. Likewise, ADHD and symptomatic GJH were associated with adjusted odds ratios of 6.94 (CI 95% 4.05-11.89, p<.005) and 2.66 (CI 95% 1.94-3.66, p<.005).

Conclusions

GJH and adult ADHD are associated conditions. Symptomatic GJH, defined as additional symptoms of pain and/or skin manifestations, has a considerably stronger link to adult ADHD than unspecific GJH has. GJH may represent a marker of an underlying systemic disorder with physical manifestations in connective tissue as well as behavioural manifestations including hyperactivity, impulsiveness and inattentiveness. Future studies should investigate if this represents a novel subtype of ADHD and if symptomatic GJH affects the ADHD management.

Disclosure

No significant relationships.

Keywords

comorbidityHypermobilityADHDbiomarkers
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S89
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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