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Affective wellbeing moderates the association between polygenic risk score for neuroticism and change in neuroticism

Published online by Cambridge University Press:  19 July 2023

J. Bahbouhová ,
M. V. Cade ,
A. T. De Sadeleer ,
C. Dibbets ,
L.-Q. Herrmann ,
P. O. F. Hovens ,
B. M. Jakson ,
R. C. Reising ,
C. Menne-Lothmann  and
J. Decoster
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J. Bahbouhová
Affiliation:
1Faculty of Health, Medicine and Life Sciences (Honours Programme)
M. V. Cade
Affiliation:
1Faculty of Health, Medicine and Life Sciences (Honours Programme)
A. T. De Sadeleer
Affiliation:
1Faculty of Health, Medicine and Life Sciences (Honours Programme)
C. Dibbets
Affiliation:
1Faculty of Health, Medicine and Life Sciences (Honours Programme)
L.-Q. Herrmann
Affiliation:
1Faculty of Health, Medicine and Life Sciences (Honours Programme)
P. O. F. Hovens
Affiliation:
1Faculty of Health, Medicine and Life Sciences (Honours Programme)
B. M. Jakson
Affiliation:
1Faculty of Health, Medicine and Life Sciences (Honours Programme)
R. C. Reising
Affiliation:
1Faculty of Health, Medicine and Life Sciences (Honours Programme)
C. Menne-Lothmann
Affiliation:
2Psychiatry and Neuropsychology, Maastricht University, Maastricht, Netherlands
J. Decoster
Affiliation:
2Psychiatry and Neuropsychology, Maastricht University, Maastricht, Netherlands
R. van Winkel
Affiliation:
2Psychiatry and Neuropsychology, Maastricht University, Maastricht, Netherlands
D. Collip
Affiliation:
2Psychiatry and Neuropsychology, Maastricht University, Maastricht, Netherlands
P. Delespaul
Affiliation:
2Psychiatry and Neuropsychology, Maastricht University, Maastricht, Netherlands
M. De Hert
Affiliation:
3University Psychiatric Centre, KU Leuven
C. Derom
Affiliation:
4Centre of Human Genetics, University Hospitals Leuven, Leuven
E. Thiery
Affiliation:
5Department of Neurology, Ghent University Hospitals, Ghent, Belgium
N. Jacobs
Affiliation:
2Psychiatry and Neuropsychology, Maastricht University, Maastricht, Netherlands
M. Wichers
Affiliation:
2Psychiatry and Neuropsychology, Maastricht University, Maastricht, Netherlands
J. van Os
Affiliation:
2Psychiatry and Neuropsychology, Maastricht University, Maastricht, Netherlands
B. P. F. Rutten
Affiliation:
2Psychiatry and Neuropsychology, Maastricht University, Maastricht, Netherlands
S. Gülöksüz
Affiliation:
2Psychiatry and Neuropsychology, Maastricht University, Maastricht, Netherlands
B. Klingenberg*
Affiliation:
2Psychiatry and Neuropsychology, Maastricht University, Maastricht, Netherlands
*
*Corresponding author.

Abstract

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Introduction

Neuroticism has societal, mental and physical health relevance, with an etiology involving genetic predisposition, psychological influence, and their interaction.

Objectives

To understand whether the association between polygenic risk score for neuroticism (PRS-N) and neuroticism is moderated by affective well-being.

Methods

Data were derived from TwinssCan, a general population twin cohort (age range=15-35 years, 478 monozygotic twins). Self-report questionnaires were used to measure well-being and neuroticism. PRS-N was trained from the Genetics of Personality Consortium (GPC) and United Kingdom Biobank (UKB). Multilevel mixed-effects models were used to test baseline and changes in well-being and neuroticism.

Results

Baseline wellbeing and neuroticism were associated (β=-1.35, p<0.001). PRSs-N were associated with baseline neuroticism (lowest p-value: 0.008 in GPC, 0.01 in UKB). In interaction models (PRS x wellbeing), GPC PRS-N (β=0.38, p=0.04) and UKB PRS-N (β=0.81, p<0.001) had significant interactions.

PRSs-N were associated with changes in neuroticism (lowest p-value: 0.03 in GPC, 0.3 in UKB). Furthermore, changes in wellbeing and neuroticism were associated (β =-0.66, p<0.001). In interaction models (PRS x change in wellbeing), only UKB PRS-N had a significant interaction (β=0.80, p<0.001).

Conclusions

Interaction between polygenic risk, wellbeing and neuroticism, were observed regarding baselines measures and change over time. Depending on the analysis step, the direction of the effect changed.

Disclosure of Interest

None Declared

Type
Abstract
Information
European Psychiatry , Volume 66 , Special Issue S1: Abstracts of the 31st European Congress of Psychiatry , March 2023 , pp. S175
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of the European Psychiatric Association
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