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1728 – Association Between Duration Of Untreated Psychosis And Progression Of Brain Volume Change In Schizophrenia - The Northern Finland 1966 Birth Cohort

Published online by Cambridge University Press:  15 April 2020

E. Jääskeläinen ,
M. Penttilä ,
M. Haapea ,
M. Isohanni ,
G. Murray ,
P. Jones ,
J. Guo ,
J. Nikkinen ,
V. Kiviniemi  and
J. Veijola
...Show all authors
E. Jääskeläinen
Affiliation:
Department of Psychiatry, Oulu, Finland
M. Penttilä
Affiliation:
Department of Psychiatry, Oulu, Finland
M. Haapea
Affiliation:
Department of Psychiatry, Oulu, Finland Department of Radiology, University of Oulu, Oulu, Finland
M. Isohanni
Affiliation:
Department of Psychiatry, Oulu, Finland Department of Psychiatry, Oulu University Hospital, Oulu, Finland
G. Murray
Affiliation:
Department of Psychiatry, University of Cambridge, Cambridge, UK
P. Jones
Affiliation:
Department of Psychiatry, University of Cambridge, Cambridge, UK
J. Guo
Affiliation:
Department of Psychiatry, University of Cambridge, Cambridge, UK
J. Nikkinen
Affiliation:
Department of Radiology, University of Oulu, Oulu, Finland
V. Kiviniemi
Affiliation:
Department of Radiology, University of Oulu, Oulu, Finland
J. Veijola
Affiliation:
Department of Psychiatry, Oulu, Finland Department of Psychiatry, Oulu University Hospital, Oulu, Finland
J. Miettunen
Affiliation:
Department of Psychiatry, Oulu, Finland Department of Psychiatry, Oulu University Hospital, Oulu, Finland Institute of Health Sciences, University of Oulu, Oulu, Finland

Abstract

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Introduction

Long duration of untreated psychosis (DUP) has been associated to brain morphological changes in schizophrenia in cross sectional analyses. It is unclear DUP relates to brain volume change over time.

Aims

Our aim was to analyze the association between length of DUP and total brain volume change in schizophrenia in a general population based sample.

Methods

All members of the Northern Finland 1966 Birth Cohort (NFBC1966) known to have had psychotic illness were invited for a field study at the age 34-years (in average 10 year after onset of psychosis) and follow up nine years later at the age 43-years. DUP was assessed from medical records. The total brain volume scan interval change and the DUP information were available for 32 subjects with DSM III R schizophrenia. We analysed the correlation between length of DUP and the mean annual whole brain reduction, adjusted for age of illness onset and sex.

Results

The mean annual whole brain volume reduction was 0.66%. The reduction was 0.76% among those with shortest DUP, 0.58% among those with median DUP, and 0.63% among those with longest DUP. There was no statistically significant correlation between DUP and annual brain volume change when adjusted for onset age and/or sex.

Conclusions

We did not find an association between long DUP and brain volume decrease in schizophrenia in 9 years follow up. Although long DUP has been associated with differences in brain volume in cross sectional analyses, the significance of DUP on brain morphology in long term is unclear.

Type
Abstract
Information
European Psychiatry , Volume 28 , Issue S1: Abstracts of the 21th European Congress of Psychiatry , 2013 , 28-E997
Copyright
Copyright © European Psychiatric Association 2013
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