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1621 – Depressive Symptoms And Cognitive Functioning In Elderly

Published online by Cambridge University Press:  15 April 2020

D. Enache ,
O. Almkvist ,
M. Gregoric Kramberger ,
V. Jelic ,
M. Eriksdotter ,
A. Lebedeva ,
F. Göthe ,
B. Winblad  and
D. Aarsland
D. Enache
Affiliation:
Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden Clinical Hospital of Psychiatry “Prof. Dr. Alexandru Obregia”, Bucharest, Romania
O. Almkvist
Affiliation:
Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
M. Gregoric Kramberger
Affiliation:
Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden Department of Neurology, University Medical Centre Ljubljana, Ljubljana, Slovenia
V. Jelic
Affiliation:
Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden Karolinska University Hospital, Geriatric Clinic, Stockholm, Sweden
M. Eriksdotter
Affiliation:
Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden Karolinska University Hospital, Geriatric Clinic, Stockholm, Sweden
A. Lebedeva
Affiliation:
Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
F. Göthe
Affiliation:
Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
B. Winblad
Affiliation:
Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
D. Aarsland
Affiliation:
Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden Centre for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway

Abstract

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Aim

To explore the associations between depressive symptoms and cognition in patients with subjective cognitive impairment (SCI), mild cognitive impairment (MCI) and with Alzheimer's disease (AD).

Methods

286 Patients (60.8% females) with SCI (n=96), MCI (n=125), AD (n=65) from a University hospital-based memory clinic were compared in several tests of cognitive performance. Mean (SD) age 67.73 (7.2) and median (range) MMSE score 28 (16-30) and Cornell Scale for Depression in Dementia (CSDD) score 5 (0-20). The three groups were subdivided into those with and without depression as evaluated by CSDD (≥12). Cognitive functions were assessed in five domains (verbal, visuospatial, short-term memory, episodic memory and executive function) based on a comprehensive battery of neuropsychological tests.

Results

A MANOVA on the five cognitive domains showed that depression vs. no depression differed significantly in the verbal (F (1,167) =4.24, p=.041) and executive (F(1,167)=17.87, p=.0001) domains. There was a significant interaction between diagnostic group, depression and cognitive domains F(2,167)=5.34, p=.006, due to a poorer performance in the executive domain for depressed MCI and AD patient compared with non depressed, but such an association was not found in SCI patients. Other markers of depression (history and current medication) did not change this pattern.

Conclusion

Depression is associated with executive function in MCI and AD patients.

Type
Abstract
Information
European Psychiatry , Volume 28 , Issue S1: Abstracts of the 21th European Congress of Psychiatry , 2013 , 28-E904
Copyright
Copyright © European Psychiatric Association 2013
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