Hostname: page-component-cd9895bd7-hc48f Total loading time: 0 Render date: 2024-12-25T02:55:06.645Z Has data issue: false hasContentIssue false
  • English
  • Français

Growth and Plasma Leptin in Yearling Mares Fed a High-Fat Supplemented Diet

Published online by Cambridge University Press:  09 March 2007

PR Buff ,
CD Morrison ,
JA Reynolds  and
DH Keisler
PR Buff
Affiliation:
Division of Animal Sciences, 160 Animal Science Research Center, University of Missouri, Columbia, MO 65211, USA
CD Morrison
Affiliation:
Pennington Biomedical Research Center, Baton Rouge, LA 70817, USA
JA Reynolds
Affiliation:
ADM Alliance Nutrition, 1000 N 30th Street, Quincy, IL 62301, USA
DH Keisler*
Affiliation:
Division of Animal Sciences, 160 Animal Science Research Center, University of Missouri, Columbia, MO 65211, USA
*
*Corresponding author: [email protected]
Get access

Abstract

Our objective was to determine if feeding a high-fat supplement versus a control supplement to growing yearling mares would affect growth an/r body composition parameters as assessed via body weight (BW), body condition scores (BCS) and concentrations of plasma hormones. Eight yearling mares were paired by initial BW (348±19kg) and maintained on pasture and supplemented with either a high-fat supplement (16% fat) or a control supplement (3% fat) at 0.8% of their BW in two daily meals for 8 weeks. Both BW and BCS increased for all mares throughout the study (each P<0.0001); however, no difference in BW or BCS could be attributed to treatment effects. Nonetheless, plasma concentrations of leptin were greater in mares fed the high-fat supplement (P = 0.0001) compared with the control supplement. Plasma concentrations of growth hormone tended to be greater in high-fat-fed mares (P = 0.06). Plasma concentrations of insulin did not differ between treatment groups (P = 0.96). Although no gross difference in BW or BCS was discernable among mares fed the control versus high-fat supplement, these data provide evidence that increasing fat content in the diet may alter leptin levels independent of changes in body composition.

Keywords

leptinequinehigh-fat dietbody condition
Type
Research Article
Information
Equine and Comparative Exercise Physiology , Volume 3 , Issue 3 , August 2006 , pp. 137 - 141
Copyright
Copyright © Cambridge University Press 2006

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1Lawrence, LM (1990). Nutrition and fuel utilization in the athletic horse. Veterinary Clininics of North America Equine Practice 6: 393–418.Google Scholar
2Kronfeld, DS, Ferrante, PL and Grandjean, D (1994). Optimal nutrition for athletic performance, with emphasis on fat adaptation in dogs and horses. Journal of Nutrition 124:(12 Suppl.) 2745S–2753S.Google Scholar
3Jeffcott, LB (1991). Osteochondrosis in the horse – searching for the key to pathogenesis. Equine Veterinary Journal 23: 331–338.Google Scholar
4Ahima, RS and Flier, JS (2000). Leptin. Annual Review of Physiology 62: 413–437.CrossRefGoogle ScholarPubMed
5Buff, PR, Dodds, AC, Morrison, CD, Whitley, NC, McFadin, EL, Daniel, JA, Djiane, J and Keisler, DH (2002). Leptin in horses: tissue localization and relationship between peripheral concentrations and body condition. Journal of Animal Science 80: 2942–2948.CrossRefGoogle ScholarPubMed
6Gentry, LR, Thompson, DL Jr, Gentry, GT Jr, Davis, KA, Godke, RA and Cartmill, JA (2002). The relationship between body condition, leptin, and reproductive and hormonal characteristics of mares during the seasonal anovulatory period. Journal of Animal Science 80: 2695–2703.Google ScholarPubMed
7Houseknecht, KL, Baile, CA, Matteri, RL and Spurlock, ME (1989). The biology of leptin: a review. Journal of Animal Science 76: 1405–1420.CrossRefGoogle Scholar
8Schwartz, MW, Woods, SC, Porte, D Jr, Seeley, RJ and Baskin, DG (2000). Central nervous system control of food intake. Nature 404: 661–671.Google Scholar
9Buff, PR, Morrison, CD, Ganjam, VK and Keisler, DH (2005). Effects of short-term feed deprivation and melatonin implants on circadian patterns of leptin in the horse. Journal of Animal Science 83: 1023–1032.CrossRefGoogle ScholarPubMed
10Cartmill, JA, Thompson, DL Jr, Storer, WA, Crowley, JC, Huff, NK and Waller, CA (2005). Effect of dexamethasone, feeding time, and insulin infusion on leptin concentration in stallions. Journal of Animal Science 83: 1875–1881.Google Scholar
11Thomas, M, Bennett-Wimbush, K, Keisler, D and Loch, W (1998). Plasma concentrations of growth hormone and insulin-like growth factor-I in prepubertal quarter horses and ponies. Journal of Equine Veterinary Science 18: 52–55.Google Scholar
12Freestone, JF, Wolfsheimer, KJ, Kamerling, SG, Church, G, Hamra, J and Bagwell, G (1991). Exercise induced hormonal and metabolic changes in Thoroughbred horses: Effects of conditioning and acepromazine. Equine Veterinary Journal 23: 219–223.Google Scholar
13Henneke, DR, Potter, GD, Kreider, JL and Yeates, BF (1983). Relationship between condition score, physical measurements and body fat percentage in mares. Equine Veterinary Journal 15: 371–372.Google Scholar
14Littell, RC, Henry, PR and Ammerman, CB (1989). Statistical analysis of repeated measures data using SAS procedures. Journal of Animal Science 76: 1216–1231.Google Scholar
15Frederich, RC, Hamann, A, Anderson, S, Löllmann, B, Lowell, BB and Flier, JS (1995). Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nature Medicine 1: 1311–1314.CrossRefGoogle ScholarPubMed
16Ahrén, B, Månsson, S, Gingerich, RL and Havel, PJ (1997). Regulation of plasma leptin in mice: influence of age, high-fat diet, and fasting. American Journal of Physiology 273: R113–R120.Google ScholarPubMed
17Scott, BD, Potter, GD, Evens, JW, Reagor, JC, Webb, GW and Webb, SP (1989). Growth and feed utilization by yearling horses fed added dietary fat. Equine Veterinary Science 9: 210–214.Google Scholar
18Ott, EA and Asquith, RL (1986). Influence of level of feeding and nutrient content of the concentrate on growth and development of yearling horses. Journal of Animal Science 62: 290–299.CrossRefGoogle ScholarPubMed
19Kennedy, GC (1953). The role of depot fat in the hypothalamic control of food intake in rats. Proceedings of the Royal Society of London, Series B 140: 578–592.Google Scholar
20Cartmill, JA, Thompson, DL Jr, Storer, WA, Gentry, LR and Huff, NK (2003). Endocrine responses in mares and geldings with high body condition scores grouped by high vs. low resting leptin concentrations. Journal of Animal Science 81: 2311–2321.CrossRefGoogle ScholarPubMed
21Taylor, RE (1994). Beef Production and Management Decisions P. 417. Upper Saddle River: Prentice Hall.Google Scholar
22Yildiz, S, Blache, D, Celebi, F, Kaya, I, Saatci, M, Cenesiz, M and Guven, B (2003). Effects of short-term high carbohydrate or fat intakes on leptin, growth hormone and luteinizing hormone secretions in prepubertal fat-tailed Tuj lambs. Reproduction in Domestic Animals 38: 182–186.CrossRefGoogle ScholarPubMed
23Kronfeld, DS, Holland, JL, Rich, GA, Meacham, TN, Fontenot, JP, Sklan, DJ and Harris, PA (2004). Fat digestibility in Equus caballus follows increasing first-order kinetics. Journal of Animal Science 82: 1773–1780.CrossRefGoogle ScholarPubMed
24Kowalczyk, J, Orskov, ER, Robinson, JJ and Stewart, CS (1977). Effect of fat supplementation on voluntary food intake and rumen metabolism in sheep. British Journal of Nutrition 37: 251–257.CrossRefGoogle ScholarPubMed
25Ropp, JK, Raub, RH and Minton, JE (2003). The effect of dietary energy source on serum concentration of insulin-like growth factor-I growth hormone, insulin, glucose, and fat metabolites in weanling horses. Journal of Animal Science 81: 1581–1589.Google Scholar
26Stull, CL and Rodiek, AV (1988). Responses of blood glucose, insulin and cortisol concentrations to common equine diets. Journal of Nutrition 118: 206–213.Google Scholar