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The time course of the humoral immune response to rhinovirus infection

Published online by Cambridge University Press:  15 May 2009

W. S. Barclay ,
W. Al-Nakib ,
P. G. Higgins  and
D. A. J. Tyrrell
W. S. Barclay*
Affiliation:
MRC Common Cold Unit, Harvard Hospital, Coombe Road, Salisbury, Wilts, SP2 8BW Department of Microbiology, University of Reading, London Road, Reading, Berks RG1 5AQ
W. Al-Nakib
Affiliation:
MRC Common Cold Unit, Harvard Hospital, Coombe Road, Salisbury, Wilts, SP2 8BW Department of Microbiology, Faculty of Medicine, University of Kuwait
P. G. Higgins
Affiliation:
MRC Common Cold Unit, Harvard Hospital, Coombe Road, Salisbury, Wilts, SP2 8BW
D. A. J. Tyrrell
Affiliation:
MRC Common Cold Unit, Harvard Hospital, Coombe Road, Salisbury, Wilts, SP2 8BW
*
*present address at Reading.
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The specific humoral immune response of 17 volunteers to infection with human rhinovirus type 2 (HRV-2) has been measured both by neutralization and by ELISA. Six volunteers who had HRV-2-specific antibodies in either serum or nasal secretions before HRV-2 inoculation were resistant to infection and illness. Of the remaining 11 volunteers who had little pre-existing HRV-2-specific antibody, one was immune but 10 became infected and displayed increases in HRV-2-specific antibodies. These antibodies first increased 1–2 weeks after infection and reached a maximum at 5 weeks. All six resistant volunteers who had high pre-existing antibody and eight of the volunteers who became infected maintained their HRV-2-specific antibody for at least 1 year. At this time they were protected against reinfection. Two volunteers showed decreases in HRV-2-specific antibodies from either serum or nasal secretions. They became infected but not ill after HRV-2 inoculation 1 year later.

Type
Research Article
Information
Epidemiology & Infection , Volume 103 , Issue 3 , December 1989 , pp. 659 - 669
Copyright
Copyright © Cambridge University Press 1989

References

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