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A Study of Meningococci occurring in the Spinal Fluid and of Similar Organisms in the Naso-pharynx1

Published online by Cambridge University Press:  15 May 2009

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(1) The maximum period during which meningococci may be isolated from the naso-pharynx of convalescents exceeds three months.

(2) Meningococci were isolated from the naso-pharynx and proved identical with those isolated from the spinal fluid of the same patient in seven cases.

(3) In two of these cases the type of meningococcus found in the naso-pharynx at first resembled exactly that found in the spinal canal of the same patient, and later was persistently replaced by a meningococcus differing markedly in serological reactions from the spinal strain.

(4) Micro-organisms indistinguishable from meningococci by microscopical and cultural methods (including fermentation tests) were found in the naso-pharynx in 22% of 138 individuals, non-contacts, from an urban population (Lambeth out-patients).

(5) With 63% of these organisms the serological tests confirmed their identity with or close relationship to meningococci; they agglutinated specifically with anti-meningococcus serum and exhibited a tendency to fall into the same serological groups as the spinal strains.

(6) Their agglutinating properties were not, in general, so strongly marked with the sera used as those of the known pathogenic strains but they showed definite absorption of the specific agglutinm. They appeared to differ from the majority of the spinal strains not in the quality but in the quantitative intensity of their specific affinities: some spinal strains, however, resembled them in this.

(7) Thus, in 13·7% of the 138 non-contacts micro-organisms were found in the naso-pharynx indistinguishable by any test from strains of meningococci known to have caused meningitis: these are regarded by the writer as meningococci and the individuals harbouring them as meningococcus-carriers.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1916

References

1 Reprinted by permission of H.M. Stationery Office, from Reports to the Local Government Board on Public Health and Medical Subjects, n. s. No. 110 (1916). Ed.