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Detoxification of an immunogenic fraction from a culture filtrate of Pseudomonas aeruginosa

Published online by Cambridge University Press:  15 May 2009

R. J. Jones
R. J. Jones
Affiliation:
Industrial Injuries and Burns Research Unit, Birmingham Accident Hospital, Birmingham 15
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Summary

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Mice immunized with a fraction from a culture filtrate of Ps. aeruginosa, then burned and infected with virulent serotypes of Ps. aeroginosa, were protected from septicaemia and death.

The immunogenic fraction killed mice at dosages 400 times those of the minimum protective dosages.

Treatment of the immunogenic fraction with 0·5% formalin reduced its lethal effect for mice and slightly improved its immunizing potency so that the difference between the smallest immunizing dose used and the smallest amount that killed mice was more than 80,000 doses.

Type
Research Article
Information
Journal of Hygiene , Volume 67 , Issue 2 , June 1969 , pp. 241 - 247
Copyright
Copyright © Cambridge University Press 1969

References

REFERENCES

Carney, S. A. & Jones, R. J. (1968). Biological and immunochemical properties of culture filtrates of virulent and avirulent strains of Pseudomonas aeruginosa. Br. J. exp. Path. 49, 395.Google ScholarPubMed
Jones, R. J. (1968). Protection against Pseudomonas aeruginosa infection by immunization with fractions of culture filtrates of Ps. aeruginosa. Br. J. exp. Path. 49, 411.Google Scholar
Jones, R. J., Jackson, D. M. & Lowbury, E. J. L. (1966). Antiserum and antibiotic in the prophylaxis of burns against Pseudomonas aeruginosa. Br. J. plast. Surg. 19, 43.Google Scholar
Jones, R. J. & Lawrence, J. C. (1964). Studies on extracts of heated and normal skin. Br. J. exp. Path. 45, 198.Google Scholar