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Comparative trials of live attenuated and detergent split influenza virus vaccines

Published online by Cambridge University Press:  15 May 2009

J. S. Mackenzie ,
Isobel Mackenzie ,
Julie Lloyd  and
Veronica Dent
J. S. Mackenzie
Affiliation:
University Department of Microbiology, Perth Medical Centre, Shenton Park, Western Australia, 6008
Isobel Mackenzie
Affiliation:
University Department of Microbiology, Perth Medical Centre, Shenton Park, Western Australia, 6008
Julie Lloyd
Affiliation:
University Department of Microbiology, Perth Medical Centre, Shenton Park, Western Australia, 6008
Veronica Dent
Affiliation:
University Department of Microbiology, Perth Medical Centre, Shenton Park, Western Australia, 6008
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Comparative clinical trials of live attenuated and detergent-split subunit influenza virus vaccines were undertaken with 1048 volunteers in Western Australia. Volunteers were divided into three main groups, each of which received either live virus vaccine or a saline control administered intranasally, or subunit vaccine injected subcutaneously. No differences were recorded between the three groups in their post-vaccination symptoms. Serum samples were collected at various times up to 50 weeks after vaccination, and antibody titres were measured by haemagglutination-inhibition (HI) tests and, for 231 volunteers, by virus neutralization tests. The two vaccines were almost equivalent in inducing seroconversion in vaccinees with pre-trial HI titres of 96 or less, but the subunit vaccine stimulated a higher geometric mean HI antibody titre. The longevity of the HI antibody response was greater for the live virus vaccine. The height of the response and the longevity of neutralizing antibody were the same for both vaccines. Both vaccines provided a high degree of protection against epidemic A/England/42/72 influenza, and some protection against A/Port Chalmers/1/73 influenza.

Type
Research Article
Information
Journal of Hygiene , Volume 75 , Issue 3 , December 1975 , pp. 425 - 444
Copyright
Copyright © Cambridge University Press 1975

References

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