Over 134 years, the United States Public Health Service (USPHS) Commissioned Corps has served as America’s adaptable, rapid-response asset for public health emergencies. This presentation outlines USPHS capabilities across key threats - from climate and infectious disease crises to border healthcare needs and national security events. It highlights response impact and priorities around training, partnerships, best practice sharing, and officer development that ready USPHS for 21st century demands. Attendees will gain insight into how specialized USPHS emergency preparedness makes it indispensable for advancing health security alongside allies globally.