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Novel Treatments for Major Depressive Disorder

Published online by Cambridge University Press:  07 November 2014

Extract

Data from a variety of studies, including the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study, have shown that fewer patients achieve remission from symptoms of major depressive disorder (MDD) and other depressive disorders after taking the first-prescribed antidepressant treatment than was expected. The goal of treatment is true remission: the complete absence of symptoms. Achieveing less than true remission is associated with MDD recurrence and continued impairment.

Type
Expert Panel Supplement
Copyright
Copyright © Cambridge University Press 2009

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References

1.Rush, AJ, Trivedi, MH, Wisniewski, SR, et al. Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report. Am J Psychiatry. 2006;163(11):19051917.CrossRefGoogle ScholarPubMed
2.Thase, ME. Therapeutic alternatives for difficult-to-treat depression: a narrative review of the state of the evidence. CNS Spectr. 2004;9(11):808816; 818–821.CrossRefGoogle ScholarPubMed
3.Bodkin, JA, Lasser, RA, Wines, JD Jr, Gardner, DM, Baldessarini, RJ. Combining serotonin reuptake inhibitors and bupropion in partial responders to antidepressant monotherapy. J Clin Psychiatry. 1997;58(4):137145.CrossRefGoogle ScholarPubMed
4.Marshall, RD, Liebowitz, MR. Paroxetine/bupropion combination treatment for refractory depression. J Clin Psychopharmacol. 1996;16(1):8081.CrossRefGoogle ScholarPubMed
5.Spier, SA. Use of bupropion with SRIs and venlafaxine. Depress Anxiety. 1998;7(2):7375.3.0.CO;2-6>CrossRefGoogle ScholarPubMed
6.Patkar, AA, Masand, PS, Pae, CU, et al. A randomized, double-blind, placebo-controlled trial of augmentation with an extended release formulation of methylphenidate in outpatients with treatment-resistant depression. J Clin Psychopharmacol. 2006;26(6):653656.CrossRefGoogle ScholarPubMed
7.DeBattista, C, Doghramji, K, Menza, MA, Rosenthal, MH, Fieve, RR, and the Modafinil in Depression Study Group. Adjunct modafinil for the short-term treatment of fatigue and sleepiness in patients with major depressive disorder: a preliminary double-blind, placebo-controlled study. J Clin Psychiatry. 2003;64(9):10571064.CrossRefGoogle ScholarPubMed
8.Shelton, RC, Papakostas, GI. Augmentation of antidepressants with atypical antipsychotics for treatment-resistant major depressive disorder. Acta Psychiatr Scand. 2008;117(4):253259.CrossRefGoogle ScholarPubMed
9.Rapaport, MH, Gharabawi, GM, Canuso, CM, et al. Effects of risperidone augmentation in patients with treatment-resistant depression: Results of open-label treatment followed by double-blind continuation. Neuropsychopharmacology. 2006;31(11):25052513.CrossRefGoogle ScholarPubMed
10.Berman, RM, Marcus, RN, Swanink, R, et al. The efficacy and safety of aripiprazole as adjunctive therapy in major depressive disorder: a multicenter, randomized, double-blind, placebo-controlled study. J Clin Psychiatry. 2007;68(6):843853.CrossRefGoogle ScholarPubMed
11.Marcus, RN, McQuade, RD, Carson, WH, et al. The efficacy and safety of aripiprazole as adjunctive therapy in major depressive disorder: a second multicenter, randomized, double-blind, placebo-controlled study. J Clin Psychopharmacol. 2008;28(2):156165.CrossRefGoogle ScholarPubMed
12.Papakostas, GI, Shelton, RC, Smith, J, Fava, M. Augmentation of antidepressants with atypical antipsy-chotic medications for treatment-resistant major depressive disorder: a meta-analysis. J Clin Psychiatry. 2007;68(6):826831.CrossRefGoogle Scholar
13.Smith, WT, Londborg, PD, Glaudin, V, Painter, JR. Short-term augmentation of fluoxetine with clonazepam in the treatment of depression: a double-blind study. Am J Psychiatry. 1998;155(10):13391345.CrossRefGoogle ScholarPubMed
14.Krystal, A, Fava, M, Rubens, R, et al. Evaluation of eszopiclone discontinuation after cotherapy with fluox-etine for insomnia with coexisting depression. J Clin Sleep Med. 2007;3(1):4855.Google Scholar
15.Lydiard, RB, Otto, MW, Milrod, B. Panic Disorder. In: Gabbard, GO, ed. Treatments of Psychiatric Disorders. 3rd ed.Arlington, VA: American Psychiatric Association; 2001:247282.Google Scholar
16.Normann, C, Hummel, B, Schärer, LO, Hörn, M, Grunze, H, Walden, J. Lamotrigine as adjunct to paroxetine in acute depression: a placebo-controlled, double-blind study. J Clin Psychiatry. 2002;63(4):337344.CrossRefGoogle ScholarPubMed
17.Fava, M. Augmenting antidepressants with folate: a clinical perspective. J Clin Psychiatry. 2007;68(suppl 10):47.Google ScholarPubMed
18.Thase, ME, Friedman, ES, Biggs, MM, et al. Cognitive therapy versus medication in augmentation and switch strategies as second-step treatments: a STAR*D report. Am J Psychiatry. 2007;164(5):739752.CrossRefGoogle Scholar
19.Marangell, LB, Martinez, M, Jurdi, RA, Zboyan, H: Neurostimulation therapies in depression: a review of new modalities. Acta Psychiatr Scand. 2007;116(3):174181.CrossRefGoogle ScholarPubMed
20.Kennedy, SH, Giacobbe, P. Treatment resistant depression--advances in somatic therapies. Ann Clin Psychiatry. 2007;19(4):279287.CrossRefGoogle ScholarPubMed