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TGF-β1 869T/C Polymorphism and Ischemic Stroke: Sex Difference in Chinese

Published online by Cambridge University Press:  23 September 2016

Hong-miao Tao ,
Guo-zhong Chen ,
Xiao-dong Lu ,
Gan-ping Chen  and
Bei Shao
Hong-miao Tao*
Affiliation:
School of Medicine, Jinhua College of Profession & Technology
Guo-zhong Chen
Affiliation:
School of Medicine, Jinhua College of Profession & Technology
Xiao-dong Lu
Affiliation:
Department of Clinical Laboratory, Jinhua Central Hospital
Gan-ping Chen
Affiliation:
Department of Neurology, Jinhua Peoples Hospital, Jinhua
Bei Shao
Affiliation:
Cerebrovascular Unit, Department of Neurology, the First Affiliated Hospital, Wenzhou Medical College, Wenzhou, Zhejiang Province, the People's Republic of China
*
School of Medicine, Jinhua College of Profession & Technology, Jinhua, 321007, Zhejiang Province, the People's Republic of China
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Abstract

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Background:

Inflammation plays a pivotal role in the pathogenesis of atherosclerosis and of cerebrovascular complications. Transforming growth factor-β (TGF-β) is a pleiotropic cytokine with a central role in inflammation. To investigate whether polymorphisms of the TGF-β1 gene can modify the risk of ischemic stroke (IS) in Chinese population, we conduct this hospital-based, case-control study.

Methods:

Transforming growth factor-β1 genotype was determined in 450 Chinese patients (306 male and 144 female) with IS and 450 control subjects (326 male and 124 female).

Results:

Subjects carrying 869TT were susceptible to IS (odds ratio [OR] =1.58; P=0.003). Further analysis of IS data partitioned by gender revealed the female-specific association with 869T/C (OR=2.64; P=0.001).

Conclusions:

Findings suggest that the TT genotype of 869T/C might be a risk factor of IS in Chinese, especially in females.

Résumé

RésuméContexte:

L'inflammation joue un rôle clé dans la pathogenèse de l'athérosclérose et des complications cérébrovasculaires. Le facteur de croissance transformant β (TGF-β) est une cytokine pléiotrope qui joue un rôle central dans l'inflammation. Nous avons effectué cette étude cas témoins en milieu hospitalier afin de déterminer si les polymorphismes du gène TGF-β1 pouvaient influencer le risque d'accident vasculaire cérébral ischémique (AVCI) dans la population chinoise.

Méthodologie:

Le génotype TGF-β1 a été déterminé chez 450 patients Chinois (306 hommes et 144 femmes) atteints d'AVCI et chez 450 témoins (326 hommes et 124 femmes).

Résultats:

Les sujets porteurs de 869TT étaient plus à risque d'AVCI (RC 1,58 ; p = 0,003). L'analyse des données selon le sexe a montré une association avec 869T/C chez les femmes (RC 2,64 ; p = 0,001).

Conclusions:

Selon ces résultats, le génotype TT de 869T/C pourrait être un facteur de risque de l'AVCI chez les Chinois, surtout chez les femmes.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 37 , Issue 6 , November 2010 , pp. 803 - 807
Copyright
Copyright © The Canadian Journal of Neurological 2010

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