Background: Care partners of people with Parkinson’s disease (PD) must continually cope with various stressors due to changes resulting from the disease process, including assisting and supporting with their medical, emotional, and social needs. Caregivers’ expectations, preferences, and experiences on PD management are a cornerstone to guarantee a comprehensive treatment of the disease and may be influenced or determined by cultural backgrounds. Methods: Comprehensive literature review to investigate the roles, experiences, and needs of caregivers of PwPD across cultures. We critically reviewed and analyzed the all published studies that examined the impact of cultural diversity on caregiving in PD. Results: Among some significant results, we found profound differences in caregivers’ experiences and perceptions between U.S, Mexican, and Latin-American, Asian, African and Indian caregivers. There are clear negative reinforced effects between caregiver status, education, health, labor participation and income-generating capacity, and social protection combined with the age and gender differences. Canadian information was not available. Conclusions: There is still a gap in the literature with a need for social and health services to understand the cultural factors that impact caregiver burden in PD to facilitate wellbeing and support from health and social services to better aid those in the caregiver role.