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Does intranasal naloxone administration increase the risk of 2019 coronavirus disease transmission?

Published online by Cambridge University Press:  12 May 2020

Yuen Chin Leong*
Affiliation:
Sunnybrook Centre for Prehospital Medicine, Sunnybrook Health Sciences Centre, Toronto, ON Faculty of Medicine, University of Toronto, Toronto, ON
P. Richard Verbeek
Affiliation:
Sunnybrook Centre for Prehospital Medicine, Sunnybrook Health Sciences Centre, Toronto, ON Division of Emergency Medicine, Department of Medicine, University of Toronto, Toronto, ON
*
Correspondence to: Dr. Yuen Chin Leong, Sunnybrook Centre for Prehospital Medicine, 77 Brown's Line, Suite 100, Toronto, ONM8W 3S2; Email: [email protected].

Abstract

Type
Letter
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
Copyright © Canadian Association of Emergency Physicians 2020

Dear Editor,

On April 3, 2020, several news outlets reported that North Bay firefighters were to stop using naloxone nasal spray as a result of the 2019 coronavirus disease (COVID-19) pandemic. This has raised concerns whether intranasal naloxone is an aerosol generating procedure (AGP) that may increase the risk of COVID-19 transmission.Reference Tran, Cimon, Severn, Pessoa-Silva and Conly1,Reference Workman, Welling and Carter2 Despite an extensive online search, we have been unable to identify any published materials that address this issue.

Naloxone is usually administered to opioid overdose patients who experience severe respiratory depression.3 Intranasal naloxone is administered by placing the patient supine, tilting the head into a sniffing position, inserting the nozzle of the device into the nostril, and pressing the plunger to release the drug. In this context, commercially available NarcanTM Nasal Spray produces particles where 90% are > 60 microns in size,Reference Amancha, Chilampalli, Potta, Yan and Goskonda4 whereas many Ontario paramedic services use the Intranasal Mucosal Atomization Device (MAD),5 which produces particles ranging from 30–100 microns. Due to the large particle size (> 20 microns),Reference Tran, Cimon, Severn, Pessoa-Silva and Conly1,Reference Workman, Welling and Carter2 each device will result in drug deposition in the nasopharyngeal cavity even if the patient inhales at the time the plunger is pressed.

Accordingly, administration of intranasal naloxone should not be considered an AGP. However, because MAD requires a higher volume of solution (1 mg/ml) compared to NarcanTM Nasal Spray (4 mg/0.1ml), we have advised paramedics to use alternative effective routes of naloxone administration (e.g., intramuscular or intravenous). Following intranasal naloxone, it is advisable to apply a surgical mask to patients who are emerging into consciousness because it has been shown that, in a simulated sneeze event,Reference Workman, Welling and Carter2 aerosol generation can extend up to 66 cm but is eliminated by a surgical mask.

It would also be prudent for all prehospital care providers to consider wearing an appropriate protective mask according to public health guidance and then to exercise physical distancing once the naloxone has been administered. Whatever the route, we also advocate that paramedics and firefighters administer naloxone as their initial step with a goal of avoiding bag-valve-mask (BVM) ventilation where appropriate because this is well known to be a high-risk AGP. The decision to assist with BVM ventilation is a difficult choice and should be done with an abundance of caution using a tight two-handed seal with minimal tidal volumes.

In conclusion, we support the administration of commercially available naloxone nasal spray as a non-AGP. It should not be withheld from patients experiencing an opioid overdose.

Competing interests

None declared.

References

REFERENCES

Tran, K, Cimon, K, Severn, M, Pessoa-Silva, CL, Conly, J. Aerosol generating procedures and risk of transmission of acute respiratory infections to healthcare workers: a systematic review. PLoS One 2012;7(4):e35797, doi:10.1371/journal.pone.0035797.CrossRefGoogle ScholarPubMed
Workman, AD, Welling, DB, Carter, BS, et al. Endonasal instrumentation and aerosolization risk in the era of COVID-19: simulation, literature review, and proposed mitigation strategies. Int Forum Allergy Rhinol 2020;epub, doi:10.1002/alr.22577.CrossRefGoogle ScholarPubMed
Product Monograph Including Patient Medication Information NarcanTM Nasal Spray. Adapt Pharma Operations Limited, Ireland; 2017. Available at: https://www.narcannasalspray.ca/pdf/en/product_monograph.pdf (accessed May 5, 2020).Google Scholar
Amancha, K, Chilampalli, S, Potta, T, Yan, N, Goskonda, VR. Liquid naloxone spray. United States; 2017. Available at: http://www.freepatentsonline.com/y2017/0252337.html (accessed May 5, 2020).Google Scholar
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