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The effect of Maillard reaction products on zinc metabolism in the rat

Published online by Cambridge University Press:  09 March 2007

D. E. Furniss ,
J. Vuichoud ,
P. A. Finot  and
R. F. Hurrell
D. E. Furniss
Affiliation:
Nestec Ltd, Nestlé Research Centre, Vers-chez-les-Blanc, CH-1000 Lausanne 26, Switzerland
J. Vuichoud
Affiliation:
Nestec Ltd, Nestlé Research Centre, Vers-chez-les-Blanc, CH-1000 Lausanne 26, Switzerland
P. A. Finot
Affiliation:
Nestec Ltd, Nestlé Research Centre, Vers-chez-les-Blanc, CH-1000 Lausanne 26, Switzerland
R. F. Hurrell
Affiliation:
Nestec Ltd, Nestlé Research Centre, Vers-chez-les-Blanc, CH-1000 Lausanne 26, Switzerland
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Abstract

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The effect of giving Maillard reaction products (MRP) on zinc metabolism was investigated in the rat. In Expt 1, MRP were prepared by incubating casein with either glucose or lactose under controlled reaction conditions, and were quantified as either ‘early’ or ‘advanced’ after estimation of lysine loss and lysine destruction respectively. In Expt 2, the effect of the purified early MRP fructose–lysine (FL) on Zn metabolism was studied. The experimental diets containing 20 mg Zn/kg were given to weanling rats for 21 d. Zn balance was assessed over 9–14 d (Expt 1), or 1–14 d (Expt 2). Femur, liver, kidney and serum Zn concentrations were determined at 21 d. The major effect of the MRP in the casein-sugar mixtures was on urinary Zn excretion. The casein-glucose MRP induced up to a 6-fold increase in the quantity of Zn excreted in the urine. The magnitude of the hyperzincuria increased with the extent of the Maillard reaction. Similar dietary levels of casein-lactose MRP increased urinary Zn loss 2-fold. Free FL had no effect on urinary Zn. Faecal Zn, Zn retention, liver, femur and serum Zn were generally not influenced by giving MRP from casein-sugar mixtures or by giving free FL, although kidney Zn was decreased in rats fed on FL. It was concluded that although urinary Zn excretion can be increased by the presence of MRP in the diet, this is only a minor excretory pathway and would have little influence on overall Zn nutrition in individuals fed on a diet adequate in Zn.

Keywords

Maillard reaction productsZinc metabolismRat
Type
Minerals: Absorption and Metabolism
Information
British Journal of Nutrition , Volume 62 , Issue 3 , November 1989 , pp. 739 - 749
Copyright
Copyright © The Nutrition Society 1989

References

REFERENCES

Adrian, J. (1974). Nutritional and physiological consequences of the Maillard reaction. World Review of Nutrition and Dietetics 19, 71–122.CrossRefGoogle ScholarPubMed
Adrian, J. & Boisselot-Lefebvres, J. (1977). Interrelations entre les produits de la réaction de Maillard et le métabolisme calcique. Cahiers de la Nutrition et Diététique XII, 233–234.Google Scholar
Andrieux, C. & Sacquet, E. (1984). Effect of Maillard's reaction products on apparent mineral absorption in different parts of the digestive tract. The role of microflora. Reproduction, Nutrition, Développement 24, 379–386.CrossRefGoogle ScholarPubMed
Duncan, D.B. (1955). Multiple range and multiple F tests. Biometrics II, 1–42.CrossRefGoogle Scholar
Eggum, B.O. (1973). A Study of Certain Factors Influencing Protein Utilisation in Rats and Pigs, National Institute of Animal Science Publication no. 406. Copenhagen, Denmark: National Institute of Animal Science.Google Scholar
Finot, P.A., Deutsch, R. & Bujard, E. (1981). The extent of the Maillard reaction during the processing of milk. In Progress in Food and Nutrition Science, vol. 5, Maillard Reactions in Food, pp. 345–355 [Eriksson, C., editor]. Oxford: Pergamon Press.Google Scholar
Finot, P.A. & Magnenat, E. (1981). Metabolic transit of early and advanced Maillard products. In Progress in Food and Nutrition Science, vol. 5, Maillard Reactions in Food, pp. 193–207 [Eriksson, C., editor]. Oxford: Pergamon Press.Google Scholar
Finot, P.A. & Mauron, J. (1969). Le blocage de la lysine par la réaction de Maillard. I. Synthèse de N−(désoxy-l-d−fructosyl-1) et N−désoxy-l-d−lactulosyl-1)-l−lysines. Helvetica Chimica Acta 52, 1488–95.CrossRefGoogle Scholar
Freeman, R.M. & Taylor, P.R. (1977). Influence of histidine administration on zinc metabolism in the rat. American Journal of Clinical Nutrition 30, 523–527.CrossRefGoogle ScholarPubMed
Furniss, D.E., Hurrell, R.F. & Finot, P.A. (1986). Modification of urinary zinc excretion in the rat associated with the feeding of Maillard reaction products. Acta Pharmacologica et Toxicologica 59, S7, 188–191.CrossRefGoogle Scholar
Hsu, J.M. & Smith, J.C. (1983). Cysteine feeding affects urinary zinc excretion in normal and ethanol treated rats. Journal of Nutrition 113, 2171–2177.CrossRefGoogle ScholarPubMed
Hurrell, R.F. (1984). Reactions of food proteins during processing and storage and their nutritional consequences. In Developments in Food Proteins, vol. 3, pp. 213–244 [Hudson, B.J.F., editor]. London: Applied Science Publishers.Google Scholar
Hurrell, R.F. & Carpenter, K.J. (1981). The estimation of available lysine in foodstuffs after Maillard reactions. In Progress in Food and Nutrition Science, vol. 5, Maillard Reactions in Food, pp. 159–177 [Eriksson, C., editor]. Oxford: Pergamon Press.Google Scholar
Hurrell, R.F., Finot, P.A. & Ford, J.E. (1983). Storage of milk powders under adverse conditions. Losses of lysine and of other essential amino acids as determined by chemical and microbiological methods. British Journal of Nutrition 49, 343–354.CrossRefGoogle ScholarPubMed
Johnson, P.E., Lykken, G., Mahalko, J., Milne, D., Inman, L., Sandstead, H.H., Garcia, W.J. & Inglett, G.E. (1983). The effect of browned and unbrowned corn products on absorption of zinc, iron and copper in humans. In The Maillard Reaction in Foods and Nutrition, pp. 349–360 [Waller, G.R. and Feather, M.S., editors]. Washington DC: American Chemical Society.CrossRefGoogle Scholar
Lykken, G.I., Mahalko, J., Johnson, P.E., Milne, D., Sandstead, H.H., Garcia, W.J., Dinitzis, F.R. & Inglett, G.E. (1986). Effect of browned and unbrowned corn products intrinsically labelled with 65Zn on absorption of 65Zn in humans. Journal of Nutrition 116, 795–801.CrossRefGoogle ScholarPubMed
Mauron, J. (1981). The Maillard reaction in food; a critical review from the nutritional standpoint. In Progress in Food and Nutrition Science, vol. 5, Maillard Reactions in Food, pp. 5–35 [Eriksson, C., editor]. Oxford: Pergamon Press.Google Scholar
Moore, S. (1963). On the determination of cysteine as cysteic acid. Journal of Biological Chemistry 238, 235–237.CrossRefGoogle Scholar
Nair, B.M., Oste, R., Asp, N.G. & Pernemalm, P.A. (1981). Absorption and distribution of a 14C-glucose lysine reaction mixture in the rat. In Progress in Food and Nutrition Science, vol. 5, Maillard Reactions in Food, pp. 217–222 [Eriksson, C., editor]. Oxford: Pergamon Press.Google Scholar
Pintauro, S.J., Lee, T.-C. & Chichester, C.O. (1983). Nutritional and toxicological effects of Maillard browned protein ingestion in the rat. In The Maillard Reaction in Foods and Nutrition, pp. 467–483 [Waller, G.R. and Feather, M.S., editors]. Washington DC: American Chemical Society.CrossRefGoogle Scholar
Stegink, L.D., Freeman, J.B., Den-Besten, L. & Filer, L.J. (1981). Maillard reaction products in parenteral nutrition. In Progress in Food and Nutrition Science, vol. 5, Maillard Reactions in Food, pp. 265–278 [Eriksson, C., editor]. Oxford: Pergamon Press.Google Scholar
Stegink, L.D., Freeman, J.B., Meyer, P.D., Filer, L.J., Fry, L.K. & Den Besten, L. (1975). Excessive trace metal ion excretion due to sugar–amino acid complexes during total parenteral nutrition. Federation Proceedings 34, 931Google Scholar
Temler, R.S., Dormond, C.A., Simon, E., Morel, B. & Mettraux, C. (1984). Response of rat pancreatic proteases to dietary proteins, their hydrolysates and soybean trypsin inhibitor. Journal of Nutrition 114, 270–278.CrossRefGoogle ScholarPubMed
Wada, L., Turnlund, J.R. & King, J.C. (1985). Zinc utilization in young men fed adequate and low zinc intakes. Journal of Nutrition 115, 1345–1354.CrossRefGoogle ScholarPubMed
Warner, R.G. & Brewer, L.H. (1972). Nutrient requirements of the laboratory rat. Nutrient Requirements of Laboratory Animals, pp. 56–93, Washington DC: National Academy of Sciences.Google Scholar
Weigand, E. & Kirchgessner, M. (1980). Total true efficiency of zinc utilization: determination and homeostatic dependence upon the zinc supply status in young rats. Journal of Nutrition 110, 469–480.CrossRefGoogle ScholarPubMed