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Alcohol and the regulation of energy balance: overnight effects on diet-induced thermogenesis and fuel storage

Published online by Cambridge University Press:  09 March 2007

P. R. Murgatroyd ,
M. L. H. M. Van De Ven ,
G. R. Goldberg  and
A. M. Prentice
P. R. Murgatroyd
Affiliation:
MRC Dunn Clinical Nutrition Centre, Hills Road, CambridgeCB2 2DH
M. L. H. M. Van De Ven
Affiliation:
MRC Dunn Clinical Nutrition Centre, Hills Road, CambridgeCB2 2DH
G. R. Goldberg
Affiliation:
MRC Dunn Clinical Nutrition Centre, Hills Road, CambridgeCB2 2DH
A. M. Prentice
Affiliation:
MRC Dunn Clinical Nutrition Centre, Hills Road, CambridgeCB2 2DH
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Abstract

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The effect of alcohol on overnight energy expenditure and substrate disposal was studied in eleven subjects (five men, six women) using whole-body indirect calorimetry for 15·5 h after test meals. Three test meals were studied in random order with at least 48 h between treatments: control, 50% of maintenance energy needs provided as 14, 40 and 46% energy from protein, fat and carbohydrate respectively; alcohol addition, control plus 23% energy as alcohol; alcohol substitution, control with alcohol replacing 23% of carbohydrate energy. ANOVA revealed no significant sex effects. Alcoholinduced thermogenesis dissipated only 15 (SD 14)% of the alcohol energy. Alcohol addition had no significant effect on protein or carbohydrate oxidation but fat oxidation was suppressed (P < 0·0005) to an extent equivalent to storing 74 (SD 51)% of the alcohol energy as fat. Alcohol substitution reduced carbohydrate oxidation (P < 0·009) to an equivalent of 42 (SD 41)% and also spared fat (P < 0·005) to an equivalent of 59 (SD 37)% of the alcohol energy. It is concluded that alcohol has no special thermogenic capacity, and that its energy can be accounted for in a similar way to carbohydrate.

Keywords

AlcoholFat storageWhole-body calorimetry
Type
Alcohol and the regulation of energy balance
Information
British Journal of Nutrition , Volume 75 , Issue 1 , January 1996 , pp. 33 - 45
Copyright
Copyright © The Nutrition Society 1996

References

REFERENCES

Badawy, A. A. B. (1978). The metabolism of alcohol. Clinics in Endocrinology and Metabolism 7, 247–271.CrossRefGoogle ScholarPubMed
Brown, D., Cole, T. J., Dauncey, M. J., Marrs, R. W. & Murgatroyd, P. R. (1984). Analysis of gaseous exchange in open circuit indirect calorimetry. Medical and Biological Engineering and Computing 22, 333–338.CrossRefGoogle ScholarPubMed
Carpenter, T. M. (1940). The metabolism of alcohol: a review. Quarterly Journalof Studies on Alcohol 1, 201–226.CrossRefGoogle Scholar
Colditz, G. A., Giovannucci, E., Rimm, E. B., Stampfer, M. J., Rosner, B., Speizer, F. E., Gordis, E. & Willett, W. C. (1991). Alcohol intake in relation to diet and obesity in women and men. American Journal of Clinical Nutrition 54, 49–55.CrossRefGoogle ScholarPubMed
Flatt, J. P. (1978). The biochemistry of energy expenditure. Recent Advances in Obesity Research, pp. 211–228. London: Newman Publishing.Google Scholar
Frezza, M., di Padova, C., Pozzato, G., Terpin, M., Baraona, E. & Leiber, C. S. (1990). High blood alcohol levels in women. The role of decreased alcohol dehydrogenase activity and first-pass metabolism. New England Journal of Medicine 322, 95–99.CrossRefGoogle ScholarPubMed
Lands, W. E. M. & Zakhari, S. (1991). The case of the missing calories. American Journal of Clinical Nutrition 54, 47–48.CrossRefGoogle ScholarPubMed
Leibel, R. L., Dufour, M., Hubbard, V. S. & Lands, W. E. M. (1993). Alcohol and calories: a matter of balance. Alcohol 10, 429–434.CrossRefGoogle ScholarPubMed
Lieber, C. S., Lasker, J. M., DeCarli, L. M., Saeli, J. & Wojtowicz, T. (1988). Role of acetone, dietary fat and total energy intake in induction of hepatic microsomal ethanol oxidising system. Journal of Pharmacological Experiments and Theories 247, 791–795.Google Scholar
Livesey, G. & Elia, M. (1988). Estimation of energy expenditure, net carbohydrate utilization, and fat oxidation and synthesis by indirect calorimetry: evaluation of errors with special reference to the detailed composition of fuels. American Journal of Clinical Nutrition 47, 608–628.CrossRefGoogle Scholar
McKenna, A. P. M., Murgatroyd, P. R., Goldberg, G. R. & Prentice, A. M. (1993). Low carbohydrate oxidation during rest: a possible mediator of weight loss in the profoundly inactive? Proceedings of the Nutrition Society 52, 280A.Google Scholar
Murgatroyd, P. R., Davies, H. L. & Prentice, A. M. (1987). Intra-individual variability and measurement noise in estimates of energy expenditure by whole body indirect calorimetry. British Journal of Nutrition 58, 347–356.CrossRefGoogle ScholarPubMed
Murgatroyd, P. R., Sonko, B. J., Wittekind, A., Goldberg, G. R., Ceesay, S. M. & Prentice, A. M. (1993). Non-invasive techniques for assessing carbohydrate flux. I. Measurement of depletion by indirect calorimetry. Acta Physiologica Scandinavica 147, 91–98.CrossRefGoogle Scholar
Rosenberg, K. & Durnin, J. V. G. A. (1978). The effect of alcohol on resting metabolic rate. British Journal of Nutrition 40, 293–298.CrossRefGoogle ScholarPubMed
Schofield, W. N., Schofield, C. & James, W. P. T. (1985). Basal metabolic rate- review and prediction, together with an annotated bibliography of source material. Human Nutrition: Clinical Nutrition 39C, Suppl. 1.Google Scholar
Shelmet, J. J., Reichard, G. A., Skutches, C. L., Hoeldtke, R. D., Owen, O. E. & Boden, G. (1988). Ethanol causes acute inhibition of carbohydrate, fat and protein oxidation and insulin resistance. Journal of Clinical Investigation 81, 1137–1145.CrossRefGoogle ScholarPubMed
Shetty, P. S., Prentice, A. M., Goldberg, G. R., Murgatroyd, P. R., McKenna, A. P. M., Stubbs, R. J. & Volschenk, P. A. (1994). Alterations in fuel selection and voluntary food intake in response to iso-energetic manipulation of glycogen stores in humans. American Journal of Clinical Nutrition 60, 534–543.CrossRefGoogle Scholar
Smart, G. (1989). Is the postwar drinking binge ending? Cross-national trends in per capita alcohol consumption. British Journal of Addiction 84, 743–748.CrossRefGoogle ScholarPubMed
Sonko, B. J., Prentice, A. M., Murgatroyd, P. R., Goldberg, G. R., van de Ven, M. L. H. M. & Coward, W. A. (1994). Effect of alcohol on postmeal fat storage. American Journal of Clinical Nutrition 59, 619–625.CrossRefGoogle ScholarPubMed
Sulkunen, P. (1976). Production, consumption and recent changes in consumption of alcoholic beverages. British Journal of Addiction 71, 115–122.Google ScholarPubMed
Suter, M. P., Schutz, Y. & Jéquier, E. (1992). The effect of ethanol on fat storage in healthy subjects. New England Journal of Medicine 326, 983–987.CrossRefGoogle ScholarPubMed
Weststrate, J. A., Wunnink, J., Duerenberg, P. & Hautvast, J. G. A. J. (1990). Alcohol and its acute effects on resting metabolic rate and diet-induced thermogenesis. British Journal of Nutrition 64, 413–425.CrossRefGoogle ScholarPubMed