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The 3-methylhistidine content of human tissues

Published online by Cambridge University Press:  09 March 2007

M. Elia ,
A. Carter  and
R. Smith
M. Elia
Affiliation:
Metabolic Unit, Nuffield Orthopaedic Caitre, Oxford
A. Carter
Affiliation:
Metabolic Unit, Nuffield Orthopaedic Caitre, Oxford
R. Smith
Affiliation:
Metabolic Unit, Nuffield Orthopaedic Caitre, Oxford
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Abstract

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1. The amount of 3-methylhistidine (3-MeH) has been measured in eighty-eight samples of tissue taken Post-mortem from five adults.

2. The highest concentration (μmol/g fat-free dry weight) of 3-MeH was in skeletal muscle (3.31 ± 0.05); intermediate values (2–3) were found in cardiac muscle and those tissues containing smooth muscle; and low values (less than I) occurred in parenchymal tissues such as liver and kidney.

3. There was little variation between the mean 3-MeH content of striated muscles in different individuals, and no significant difference between the 3-MeH concentrations of striated muscles taken from six different sites.

4. The results suggest that it is justifiable to use values obtained from single muscles to calculate the rate of myofibrillar breakdown from urinary 3-MeH excretion.

Type
Short Paper
Information
British Journal of Nutrition , Volume 42 , Issue 3 , November 1979 , pp. 567 - 570
Copyright
Copyright © The Nutrition Society 1979

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