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The ketamine model for schizophrenia

Published online by Cambridge University Press:  03 September 2003

Murray Alpert  and
Burt Angrist
Murray Alpert
Affiliation:
Department of Psychiatry, NYU School of Medicine, New York, NY 10016 [email protected]
Burt Angrist
Affiliation:
Department of Psychiatry, NYU School of Medicine, New York, NY 10016 [email protected]
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Abstract

This commentary compares clinical aspects of ketamine with the amphetamine model of schizophrenia. Hallucinations and loss of insight, associated with amphetamine, seem more schizophrenia-like. Flat affect encountered with ketamine is closer to the clinical presentation in schizophrenia. We argue that flat affect is not a sign of schizophrenia, but rather, a risk factor for chronic schizophrenia.

Type
Article Commentary
Information
Behavioral and Brain Sciences , Volume 26 , Issue 1 , February 2003 , pp. 82 - 83
Copyright
Copyright © Cambridge University Press 2003

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