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State-dependent suppression of LTP induction after learning: Relation to phasic hippocampal network events

Published online by Cambridge University Press:  01 December 1997

Clive R. Bramham
Clive R. Bramham
Affiliation:
Department of Physiology, University of Bergen, N-5009 Bergen, [email protected]
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Abstract

This commentary argues that (1) arousal is not sufficient to induce LTP in the hippocampus, (2) learning can profoundly modulate synaptic plasticity in a state-dependent manner without affecting baseline synaptic efficacy, and (3) unilateral, synapse-specific LTP induction triggers an interhippocampal communication manifested as bilateral increases in gene expression at multiple sites in the hippocampal network.

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 20 , Issue 4 , December 1997 , pp. 614 - 615
Copyright
© 1997 Cambridge University Press

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