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Is the lifetime of light-stimulated cGMP phosphodiesterase regulated by recoverin through its regulation of rhodopsin phosphorylation?

Published online by Cambridge University Press:  04 February 2010

Akio Yamazaki
Akio Yamazaki*
Affiliation:
Kresge Eye Institute, Department of Ophthalmology and Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201
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Abstract

In the current model of visual transduction, the lifetime of active cGMP phosphodiesterase depends upon the period of its interaction with GTP-bound transducin. If recoverin regulates the lifetime of light-activated cGMP phosphodiesterase through inhibition of rhodopsin phosphorylation, rhodopsin should directly interact with cGMP phosphodiesterase and/or GTP-bound transducin complexed with cGMP phosphodiesterase. Is this true?

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Article Commentary
Information
Behavioral and Brain Sciences , Volume 18 , Special Issue 3: An International Journal of Current Research and Theory with Open Peer Commentary , September 1995 , pp. 494
Copyright
Copyright © Cambridge University Press 1995

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