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Are intrinsic inhibitory systems activated or inhibited in pathological pain states?

Published online by Cambridge University Press:  01 September 1997

K. Omote
K. Omote
Affiliation:
Department of Anesthesiology, Sapporo Medical University School of Medicine, South-1, West-16, Chuoku, Sapporo, 060 [email protected]
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Abstract

Neuroplastic changes in the inhibitory systems contribute to pathological pains such as hyperalgesia. Activation or inhibition of the intrinsic inhibitory systems may depend on the pathophysiology which induces a sustained pain state. The mechanisms of hyperalgesia, opioid insensitivity following nerve injury, and opioid tolerance may be related to common neuroplastic changes. [wiesenfeld-hallin et al.]

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 20 , Issue 3 , September 1997 , pp. 461 - 462
Copyright
© 1997 Cambridge University Press

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