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Swine vesicular disease virus. Pathology of the disease and molecular characteristics of the virion

Published online by Cambridge University Press:  28 February 2007

Estela Escribano-Romero ,
Miguel Angel Jiménez-Clavero  and
Victoria Ley
Estela Escribano-Romero
Affiliation:
Instituto Nacional de Investigaciones Agrarias y Alimentarias, 28040, Madrid, Spain
Miguel Angel Jiménez-Clavero
Affiliation:
Instituto Nacional de Investigaciones Agrarias y Alimentarias, 28040, Madrid, Spain
Victoria Ley*
Affiliation:
Instituto Nacional de Investigaciones Agrarias y Alimentarias, 28040, Madrid, Spain
*
*INIA, Crta Coruña Km 7.5, 28040 Madrid, Spain e-mail: [email protected]
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Abstract

Swine vesicular disease is a highly contagious disease of pigs that is caused by an enterovirus of the family Picornaviridae. The virus is a relatively recent derivative of the human coxsackievirus B5, with which it has high molecular and antigenic homology. The disease is not severe, and affected animals usually show moderate general weakening and slight weight loss that is recovered in few days, as well as vesicular lesions in the mucosa of the mouth and nose and in the interdigital spaces of the feet. However, the similarity of these lesions to those caused by foot-and-mouth disease virus has led to the inclusion of this virus in list A of the Office International des Epizooties. The disease has been eradicated in the European Union except in Italy, where it is considered endemic in the south. Nevertheless, as occasional outbreaks still appear and must be eliminated rapidly, European countries are on the alert and farms are monitored routinely for the presence of the virus. This circumstance has led to a considerable effort to study the pathology of the disease and the molecular biology and antigenicity of the virus, and to the development of optimized methods for the diagnosis of the infection.

Type
Research Article
Information
Animal Health Research Reviews , Volume 1 , Issue 2 , December 2000 , pp. 119 - 126
Copyright
Copyright © CAB International 2000

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References

Andries, K, Dewindt, B, Snoeks, J, Willebrords, R, van Eemeren, K, Stokbroekx, R and Janssen, PA (1992). In vitro activity of pirodavir (R 77975), a substituted phenoxypyridazinamine with broad-spectrum antipicornaviral activity. Antimicrobial Agents and Chemotherapy 36: 100–107.Google Scholar
Baranowski, E, Ruiz-Jarabo, CM, Sevilla, N, Andreu, D, Beck, E and Domingo, E (2000). Cell recognition by foot-and-mouth disease virus that lacks the RGD integrin-binding motif: flexibility in aphthovirus receptor usage. Journal of Virology 74: 1641–1647.Google Scholar
Belnap, DM, Filman, DJ, Trus, BL, Cheng, N, Booy, FP, Conway, JF, Curry, S, Hiremath, CN, Tsang, SK, Steven, AC and Hogle, JM (2000). Molecular tectonic model of virus structural transitions: the putative cell entry states of poliovirus. Journal of Virology 74: 1342–1354.Google Scholar
Bergelson, JM, Cunningham, JA, Droguett, G, Kurt-Jones, EA, Krithivas, A, Hong, JS, Horwitz, MS, Crowell, RL and Finberg, RW (1997 a). Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5. Science 275: 1320–1323.Google Scholar
Bergelson, JM, Modlin, JF, Wieland-Alter, W, Cunningham, JA, Crowell, RL and Finberg, RW (1997 b). Clinical coxsackievirus B isolates differ from laboratory strains in their interaction with two cell surface receptors. Journal of Infectious Diseases 175: 697–700.Google Scholar
Brocchi, E, Berlinzani, A, Gamba, D and De Simone, F (1995). Development of two novel monoclonal antibody-based ELISAs for the detection of antibodies and the identification of swine isotypes against swine vesicular disease virus. Journal of Virological Methods 52: 155–167.Google Scholar
Brocchi, E, Zhang, G, Knowles, NJ, Wilsden, G, McCauley, JW, Marquardt, O, Ohlinger, VF and De Simone, F (1997). Molecular epidemiology of recent outbreaks of swine vesicular disease: two genetically and antigenically distinct variants in Europe, 1987–1994. Epidemiology and Infection 118: 51–61.CrossRefGoogle Scholar
Brown, F, Talbot, P and Burrows, R (1973). Antigenic differences between isolates of swine vesicular disease virus and their relationship to Coxsackie B5 virus. Nature 245: 315–316.CrossRefGoogle ScholarPubMed
Burrows, R, Greig, A and Goodridge, D (1973). Swine vesicular disease. Research in Veterinary Science 15: 141–144.Google Scholar
Byrnes, AP and Griffin, DE (1998). Binding of Sindbis virus to cell surface heparan sulfate. Journal of Virology 72: 7349–7356.CrossRefGoogle ScholarPubMed
Carson, SD, Chapman, NN and Tracy, SM (1997). Purification of the putative coxsackievirus B receptor from HeLa cells. Biochemical and Biophysical Research Communications 233: 325–328.CrossRefGoogle ScholarPubMed
Chen, Y, Maguire, T, Hileman, RE, Fromm, JR, Esko, JD, Linhardt, RJ and Marks, RM (1997). Dengue virus infectivity depends on envelope protein binding to target cell heparan sulfate [see comments]. Nature Medicine 3: 866–871.Google Scholar
Chow, M, Yabrov, R, Bittle, J, Hogle, J and Baltimore, D (1985). Synthetic peptides from four separate regions of the poliovirus type 1 capsid protein VP1 induce neutralizing antibodies. Proceedings of the National Academy of Sciences of the United States of America 82: 910–914.CrossRefGoogle ScholarPubMed
Chu, RM, Moore, DM and Conroy, JD (1979). Experimental swine vesicular disease, pathology and immunofluorescence studies. Canadian Journal of Comparative Medicine 43: 29–38.Google ScholarPubMed
Chung, CS, Hsiao, JC, Chang, YS and Chang, W (1998). A27L protein mediates vaccinia virus interaction with cell surface heparan sulfate. Journal of Virology 72: 1577–1585.CrossRefGoogle ScholarPubMed
Combs, GP (1973). A study of swine vesicular disease in England. Proceedings, Annual Meeting Of The United States Animal Health Association, 1973, pp. 332–335.Google Scholar
Compton, T, Nowlin, DM and Cooper, NR (1993). Initiation of human cytomegalovirus infection requires initial interaction with cell surface heparan sulfate. Virology 193: 834–841.Google Scholar
Crowell, RL and Philipson, L (1971). Specific alterations of coxsackievirus B3 eluted from HeLa cells. Journal of Virology 8: 509–515.CrossRefGoogle ScholarPubMed
Dawe, PS, Forman, AJ and Smale, CJ (1973). A preliminary investigation of the swine vesicular disease epidemic in Britain. Nature 241: 540–542.Google Scholar
De Clercq, K (1998). Reduction of singleton reactors against swine vesicular disease virus by a combination of virus neutralisation test, monoclonal antibody-based competitive ELISA and isotype specific ELISA. Journal of Virological Methods 70: 7–18.Google Scholar
Dekker, A, Moonen, P, de Boer-Luijtze, EA and Terpstra, C (1995). Pathogenesis of swine vesicular disease after exposure of pigs to an infected environment. Veterinary Microbiology 45: 243–250.CrossRefGoogle Scholar
Fricks, CE and Hogle, JM (1990). Cell-induced conformational change in poliovirus: externalization of the amino terminus of VP1 is responsible for liposome binding. Journal of Virology 64: 1934–1945.CrossRefGoogle ScholarPubMed
Fry, EE, Lea, SM, Jackson, T, Newman, JW, Ellard, FM, Blakemore, WE, Abu-Ghazaleh, R, Samuel, A, King, AM and Stuart, DI (1999). The structure and function of a foot-and-mouth disease virus–oligosaccharide receptor complex. EMBO Journal 18: 543–554.CrossRefGoogle ScholarPubMed
Graves, JH (1973). Serological relationship of swine vesicular disease virus and Coxsackie B5 virus. Nature 245: 314–315.CrossRefGoogle ScholarPubMed
Haywood, AM (1994). Virus receptors: binding, adhesion strengthening, and changes in viral structure. Journal of Virology 68: 1–5.CrossRefGoogle ScholarPubMed
Heckert, RA, Brocchi, E, Berlinzani, A and Mackay, DK (1998). An international comparative analysis of a competitive ELISA for the detection of antibodies to swine vesicular disease virus. Journal of Veterinary Diagnosis and Investigation 10: 295–297.CrossRefGoogle ScholarPubMed
Heinz, BA, Rueckert, RR, Shepard, DA, Dutko, FJ, McKinlay, MA, Fancher, M, Rossmann, MG, Badger, J and Smith, TJ (1989). Genetic and molecular analyses of spontaneous mutants of human rhinovirus 14 that are resistant to an antiviral compound. Journal of Virology 63: 2476–2485.Google Scholar
Hogle, JM, Chow, M and Filman, DJ (1985). Three-dimensional structure of poliovirus at 2.9 A resolution. Science 229: 1358–1365.Google Scholar
House, JA and House, CA (1992). Vesicular Diseases, 7th edn. Ames (IA): Iowa State University Press.Google Scholar
Inoue, T, Suzuki, T and Sekiguchi, K (1989). The complete nucleotide sequence of swine vesicular disease virus. Journal of General Virology 70: 919–934.CrossRefGoogle ScholarPubMed
Inoue, T, Yamaguchi, S, Kanno, T, Sugita, S and Saeki, T (1993). The complete nucleotide sequence of a pathogenic swine vesicular disease virus isolated in Japan (J1'73) and phylogenetic analysis. Nucleic Acids Research 21: 3896–3901.CrossRefGoogle ScholarPubMed
Jackson, T, Ellard, FM, Ghazaleh, RA, Brookes, SM, Blakemore, WE, Corteyn, AH, Stuart, DI, Newman, JW and King, AM (1996). Efficient infection of cells in culture by type O foot-and-mouth disease virus requires binding to cell surface heparan sulfate. Journal of Virology 70: 5282–5287.Google Scholar
Jiménez-Clavero, MA, Douglas, A, Lavery, T, Garcia-Ranea, JA and Ley, V (2000). Immune recognition of swine vesicular disease virus structural proteins: novel antigenic regions that are not exposed in the capsid. Virology 270: 76–83.Google Scholar
Jimenez-Clavero, MA, Escribano-Romero, E, Douglas, AJ and Ley, V (2001). The N-terminal region of the VP1 protein of swine vesicular disease virus contains a neutralization site that arises upon cell attachment and is involved in viral entry. Journal of Virology 75: 1044–1047.CrossRefGoogle ScholarPubMed
Kanno, T, Inoue, T, Wang, Y, Sarai, A and Yamaguchi, S (1995). Identification of the location of antigenic sites of swine vesicular disease virus with neutralization-resistant mutants. Journal of General Virology 76: 3099–3106.CrossRefGoogle ScholarPubMed
Knowles, NJ and McCauley, JW (1997). Coxsackievirus B5 and the relationship to swine vesicular disease virus. Current Topics in Microbiology and Immunology 223: 153–167.Google Scholar
Kodama, M, Ogawa, T, Saito, T, Tokuda, G and Sasahara, J (1980 a). Swine vesicular disease viruses isolated from healthy pigs in non-epizootic period. I. Isolation and identification. National Institute of Animal Health Quarterly 20: 1–10.Google Scholar
Kodama, M, Saito, T, Ogawa, T, Tokuda, G, Sasahara, J and Kumagai, T (1980 b). Swine vesicular disease viruses isolated from healthy pigs in non-epizootic period. II. Vesicular formation and virus multiplication in experimentally inoculated pigs. National Institute of Animal Health Quarterly 20: 123–130.Google Scholar
Lai, SS, McKercher, PD, Moore, DM and Gillespie, JH (1979). Pathogenesis of swine vesicular disease in pigs. American Journal of Veterinary Research 40: 463–468.Google ScholarPubMed
Li, Q, Yafal, AG, Lee, YM, Hogle, J and Chow, M (1994). Poliovirus neutralization by antibodies to internal epitopes of VP4 and VP1 results from reversible exposure of these sequences at physiological temperature. Journal of Virology 68: 3965–3970.Google Scholar
Lin, F, Mackay, DK and Knowles, NJ (1997). Detection of swine vesicular disease virus RNA by reverse transcription– polymerase chain reaction. Journal of Virological Methods 65: 111–121.Google Scholar
Lin, F, Mackay, DK and Knowles, NJ (1998). The persistence of swine vesicular disease virus infection in pigs. Epidemiology and Infection 121: 459–472.CrossRefGoogle ScholarPubMed
Lonberg-Holm, K and Korant, BD (1972). Early interaction of rhinovirus with host cells. Journal of Virology 9: 29–40.CrossRefGoogle ScholarPubMed
Mackay, DK, Armstrong, RM and Kilner, CG (1995). Serological survey for swine vesicular disease in the UK. Veterinary Record 136: 248–249.Google Scholar
Mann, JA and Hutchings, GH (1980). Swine vesicular disease: pathways of infection. Journal of Hygiene 84: 355–363.Google Scholar
Martino, TA, Petric, M, Brown, M, Aitken, K, Gauntt, CJ, Richardson, CD, Chow, LH and Liu, PP (1998). Cardiovirulent coxsackieviruses and the decay-accelerating factor (CD55) receptor. Virology 244: 302–314.Google Scholar
Martino, TA, Petric, M, Weingartl, H, Bergelson, JM, Opavsky, MA, Richardson, CD, Modlin, JF, Finberg, RW, Kain, KC, Willis, N, Gauntt, CJ and Liu, PP (2000). The coxsackie-adenovirus receptor (CAR) is used by reference strains and clinical isolates representing all six serotypes of coxsackievirus group B and by swine vesicular disease virus. Virology 271: 99–108.CrossRefGoogle Scholar
McKercher, PD, Blackwell, JH and Murphy, R (1985). Survival of SVDV in ‘prosciutto di Parma’ (Parma ham). Canadian Institute of Food Science and Technology Journal 18: 163–167.CrossRefGoogle Scholar
McKercher, PD, Graves, JH, Callis, JJ and Carmichael, F (1974). Swine vesicular disease: virus survival in pork products. Proceedings, Annual Meeting of the United States Animal Health Association, 1974, pp. 213a–213g.Google Scholar
Minor, PD, Ferguson, M, Evans, DM, Almond, JW and Icenogle, JP (1986). Antigenic structure of polioviruses of serotypes 1, 2 and 3. Journal of General Virology 67: 1283–1291.CrossRefGoogle Scholar
Mondor, I, Ugolini, S and Sattentau, QJ (1998). Human immunodeficiency virus type 1 attachment to HeLa CD4 cells is CD4 independent and gp120 dependent and requires cell surface heparans. Journal of Virology 72: 3623–3634.Google Scholar
Muckelbauer, JK, Kremer, M, Minor, I, Diana, G, Dutko, FJ, Groarke, J, Pevear, DC and Rossmann, MG (1995). The structure of coxsackievirus B3 at 3.5 A resolution. Structure 3: 653–667.Google Scholar
Mulder, WA, van Poelwijk, F, Moormann, RJ, Reus, B, Kok, GL, Pol, JM and Dekker, A (1997). Detection of early infection of swine vesicular disease virus in porcine cells and skin sections. A comparison of immunohistochemistry and in-situ hybridization. Journal of Virological Methods 68: 169–175.Google Scholar
Nardelli, L, Lodetti, E, Gualandi, GL, Burrows, R, Goodridge, D, Brown, F and Cartwright, B (1968). A foot and mouth disease syndrome in pigs caused by an enterovirus. Nature 219: 1275–1276.Google Scholar
Nijhar, SK, Mackay, DK, Brocchi, E, Ferris, NP, Kitching, RP and Knowles, NJ (1999). Identification of neutralizing epitopes on a European strain of swine vesicular disease virus. Journal of General Virology 80: 277–282.Google Scholar
Núñez, JI, Blanco, E, Hernández, T, Gómez-Tejedor, C, Martín, MJ, Dopazo, J and Sobrino, F (1998). A RT-PCR assay for the differential diagnosis of vesicular viral diseases of swine. Journal of Virological Methods 72: 227–235.CrossRefGoogle ScholarPubMed
Peitsch, MC (1996). ProMod and Swiss-Model: Internet-based tools for automated comparative protein modelling. Biochemical Society Transactions 24: 274–279.CrossRefGoogle ScholarPubMed
Phelps, DK and Post, CB (1995). A novel basis of capsid stabilization by antiviral compounds. Journal of Molecular Biology 254: 544–551.Google Scholar
Pulli, T, Roivainen, M, Hovi, T and Hyypia, T (1998). Induction of neutralizing antibodies by synthetic peptides representing the C terminus of coxsackievirus A9 capsid protein VP1. Journal of General Virology 79: 2249–2253.CrossRefGoogle Scholar
Roelvink, PW, Lizonova, A, Lee, JG, Li, Y, Bergelson, JM, Finberg, RW, Brough, DE, Kovesdi, I and Wickham, TJ (1998). The coxsackievirus-adenovirus receptor protein can function as a cellular attachment protein for adenovirus serotypes from subgroups A, C, D, E, and F. Journal of Virology 72: 7909–7915.CrossRefGoogle Scholar
Roivainen, M, Narvanen, A, Korkolainen, M, Huhtala, ML and Hovi, T (1991). Antigenic regions of poliovirus type 3/ Sabin capsid proteins recognized by human sera in the peptide scanning technique. Virology 180: 99–107.CrossRefGoogle ScholarPubMed
Roivainen, M, Piirainen, L, Rysa, T, Narvanen, A and Hovi, T (1993). An immunodominant N-terminal region of VP1 protein of poliovirion that is buried in crystal structure can be exposed in solution. Virology 195: 762–765.Google Scholar
Rossmann, MG, Arnold, E, Erickson, JW, Frankenberger, EA, Griffith, JP, Hecht, HJ, Johnson, JE, Kamer, G, Luo, M and Mosser, AG (1985). Structure of a human common cold virus and functional relationship to other picornaviruses. Nature 317: 145–153.Google Scholar
Seechurn, P, Knowles, NJ and McCauley, JW (1990). The complete nucleotide sequence of a pathogenic swine vesicular disease virus. Virus Research 16: 255–274.Google Scholar
Sellers, RF and Herniman, KA (1974). The airborne excretion by pigs of swine vesicular disease virus. Journal of Hygiene 72: 61–65.Google Scholar
Shafren, DR, Bates, RC, Agrez, MV, Herd, RL, Burns, GF and Barry, RD (1995). Coxsackieviruses B1, B3, and B5 use decay accelerating factor as a receptor for cell attachment. Journal of Virology 69: 3873–3877.CrossRefGoogle ScholarPubMed
Shukla, D, Liu, J, Blaiklock, P, Shworak, NW, Bai, X, Esko, JD, Cohen, GH, Eisenberg, RJ, Rosenberg, RD and Spear, PG (1999). A novel role for 3-O-sulfated heparan sulfate in herpes simplex virus 1 entry. Cell 99: 13–22.Google Scholar
Summerford, C and Samulski, RJ (1998). Membrane-associated heparan sulfate proteoglycan is a receptor for adeno-associated virus type 2 virions. Journal of Virology 72: 1438–1445.Google Scholar
Tomko, RP, Xu, R and Philipson, L (1997). HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses. Proceedings of the National Academy of Sciences of the United States of America 94: 3352–3356.Google Scholar
Tsang, SK, Danthi, P, Chow, M and Hogle, JM (2000). Stabilization of poliovirus by capsid-binding antiviral drugs is due to entropic effects. Journal of Molecular Biology 296: 335–340.Google Scholar
Tsuda, T, Tokui, T and Onodera, T (1987). Induction of neutralizing antibodies by structural proteins VP1 and VP2 of swine vesicular disease virus. Nippon Juigaku Zasshi, Japanese Journal of Veterinary Science 49: 129–132.Google ScholarPubMed
Zhang, G, Wilsden, G, Knowles, NJ and McCauley, JW (1993). Complete nucleotide sequence of a coxsackie B5 virus and its relationship to swine vesicular disease virus. Journal of General Virology 74: 845–853.Google Scholar
Zhang, G, Haydon, DT, Knowles, NJ and McCauley, JW (1999). Molecular evolution of swine vesicular disease virus. Journal of General Virology 80: 639–651.Google Scholar
Zhao, R, Pevear, D, Kremer, M, Giranda, V, Kofron, J, Kuhn, R and Rossmann, MG (1996). Human rhinovirus 3 at 3.0 A resolution. Structure 4: 1205–1220.Google Scholar