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Evolution and function of tandem repeats in the major surface protein 1a of the ehrlichial pathogen Anaplasma marginale

Published online by Cambridge University Press:  28 February 2007

José de la Fuente ,
Jose C. Garcia-Garcia ,
Edmour F. Blouin ,
Sergio D. Rodríguez ,
Migel A. García  and
Katherine M. Kocan
José de la Fuente*
Affiliation:
Department of Veterinary Pathobiology, College of Veterinary Medicine Oklahoma State University, Stillwater, OK, 74078, USA
Jose C. Garcia-Garcia
Affiliation:
Department of Veterinary Pathobiology, College of Veterinary Medicine Oklahoma State University, Stillwater, OK, 74078, USA
Edmour F. Blouin
Affiliation:
Department of Veterinary Pathobiology, College of Veterinary Medicine Oklahoma State University, Stillwater, OK, 74078, USA
Sergio D. Rodríguez
Affiliation:
CENID-Parasitología Veterinaria, Instituto Nacional de Investigaciones Forestales, Agrícolas y Pecuarias, SAGARPA, Ado., CIVAC 62550, Jiutepec, Morelos, Postal 206, Mexico
Migel A. García
Affiliation:
CENID-Parasitología Veterinaria, Instituto Nacional de Investigaciones Forestales, Agrícolas y Pecuarias, SAGARPA, Ado., CIVAC 62550, Jiutepec, Morelos, Postal 206, Mexico
Katherine M. Kocan
Affiliation:
Department of Veterinary Pathobiology, College of Veterinary Medicine Oklahoma State University, Stillwater, OK, 74078, USA
*
*E-mail: [email protected]
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Abstract

The major surface protein (MSP) 1a of the ehrlichial cattle pathogen Anaplasma marginale, encoded by the single-copy gene msp1α, has been shown to have a neutralization-sensitive epitope and to be an adhesin for bovine erythrocytes and tick cells. msp1α has been found to be a stable genetic marker for the identification of geographic isolates of A. marginale throughout development in acutely and persistently infected cattle and in ticks. The molecular weight of MSP1a varies among geographic isolates of A. marginale because of a varying number of tandemly repeated peptides of 28–29 amino acids. Variation in the sequence of the tandem repeats occurs within and among isolates, and may have resulted from evolutionary pressures exerted by ligand–receptor and host–parasite interactions. These repeated sequences include markers for tick transmissibility that may be important in the identification of ehrlichial pathogens because they may influence control strategies and the design of subunit vaccines.

Type
Research Article
Information
Animal Health Research Reviews , Volume 2 , Issue 2 , December 2001 , pp. 163 - 174
Copyright
Copyright © CAB International 2001

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