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The Use of Microsatellites in Zygosity Diagnosis of Twins

Published online by Cambridge University Press:  06 September 2016

J. Erdmann ,
M.M. Nöthen ,
M. Stratmann ,
R. Fimmers ,
E. Franzek  and
P. Propping
J. Erdmann*
Affiliation:
Institutes of Human Genetics
M.M. Nöthen
Affiliation:
Institutes of Human Genetics
M. Stratmann
Affiliation:
Institutes of Human Genetics
R. Fimmers
Affiliation:
Medical Statistics, University of Bonn
E. Franzek
Affiliation:
Department of Psychiatry, University of Würzburg, Germany
P. Propping
Affiliation:
Institutes of Human Genetics
*
Institute of Human Genetics, University of Bonn, Wilhelmstr. 31, 5311 Bonn, Germany

Abstract

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Although numerous genetic and anthropological markers are available for determining zygosity of twins, there is still a need for a more practical and informative method in zygosity diagnosis. Dinucleotide repeats or other short repeats (microsatellites) are highly variable between individuals and offer a simple, fast, cheap, and exact approach for zygosity determination. The feasibility of a set of microsatellites to be used for this purpose is demonstrated.

Keywords

TwinsZygosity diagnosisPolymerase-chain-reaction (PCR)Highly polymorphic genetic markersDinucleotide repeats
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 42 , Issue 1 , 1993 , pp. 45 - 51
Copyright
Copyright © The International Society for Twin Studies 1993

References

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