Hostname: page-component-586b7cd67f-dlnhk Total loading time: 0 Render date: 2024-11-23T17:23:57.840Z Has data issue: false hasContentIssue false
  • English
  • Français

Monozygotic Heterocaryotic Twinning

Published online by Cambridge University Press:  01 August 2014

J. Lejeune  and
A. Aurias
J. Lejeune*
Affiliation:
Institut de Progénèse, Université de Paris, France
A. Aurias
Affiliation:
Institut de Progénèse, Université de Paris, France
*
Institut de Progénèse, 15 Rue de l'Ecole de Médecine, Paris 75006, France

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Since the first publication in 1961, cases of monozygotic heterocaryotic twinning have been repeatedly found and a total of 14 observations can now be analysed. The mechanism involved in this type of twinning is yet uncertain and eventually is not identical in each case, the main uncertainty being to decide whether the chromosomal error affecting one of the twins is related, directly or indirectly, to the process of MZ twinning per se. Regarding the time of occurrence, the error seems to occur at few days of development at the most and, in one case at least, was contemporary to the first division cleavage. Considering the possibility of twins of different sex (e.g., one XY and one XO) the MZ heterocaryotic twinning could be considered as a potential equivalent of autofecundation in species in which the XO is a fertile female. Evolutive implications shall be discussed.

Type
2. The Twinning Phenomenon
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 25 , Issue 1 , January 1976 , pp. 50 - 52
Copyright
Copyright © The International Society for Twin Studies 1976

References

BIBLIOGRAPHIE

Aurias, A. 1974. Contribution à l'étude du mécanisme et de la signification du monozygotisme hétérocaryote. Thèse pour le Doctorat en Médecine (Paris).Google Scholar
Bourdy, J. J. 1969. Contribution à l'étude du monozygotisme hétérocaryote. A propos d'un couple fille normale-syndrome de Turner. Thèse pour le Doctorat en Médecine (Paris).Google Scholar
Dekaban, A. 1965. Twins probably monozygotic: one mongoloid with 48 chromosomes; the other normal. Cytogenetics, 4: 228–239.CrossRefGoogle ScholarPubMed
Dent, T., Edwards, J.H. 1963. Monozygotic twins of different sex. Proc. 11th Int. Congr. of Genetics [Vol. 1, p. 304]. London: Pergamon Press.Google Scholar
Edwards, J.H. 1964. Communication personnelle.Google Scholar
Edwards, J.H., Dent., T., Kahn, J. 1966. Monozygotic twins of different sex. J. Med. Genet., 3: 117–123.CrossRefGoogle ScholarPubMed
Ker Melville, G., Nabil Rashad, M. 1966. Autosomal trisomy in a discordant monozygotic twin. Nature, 212: 727.Google Scholar
Lejeune, J., Turpin, R. 1961. Détection chromosomique d'une mosaïque artificielle humaine. C.R. Acad. Sci. (Paris), 252: 3148.Google Scholar
Lejeune, J., Lafourcade, J., Scharer, K., Wolff, E., Salmon, C. Haines, M., Turpin, R. 1962. Monozygotisme hétérocaryote: jumeau normal et trisomique 21. C.R. Acad. Sci. (Paris), 254: 4404–4406.Google Scholar
Lejeune, J. 1968. Adam et Eve ou le monogénisme. Nouvelle Revue Théologique, 90/2.Google Scholar
Lejeune, J., Dutrillaux, B., Réthoré, M.O., Prieur, M. 1973. Comparaison de la structure fine des chromatides d'Homo sapiens et de Pan troglodytes. Chromosoma (Berlin), 43: 423–444.CrossRefGoogle Scholar
Lejeune, J. 1975. Sur les mécanismes de la spéciation. C.R. Soc. Biologie, 169: 828–844.Google Scholar
Mikkelsen, M., Froland, A., Ellebjerg, J. 1963. XO/XX mosaicism in a pair of presumably monozygotic twins with different phenotypes. Cytogenetics, 2: 86–98.CrossRefGoogle Scholar
Ross, G.T., Tjio, J.H., Lipsett, M.B. 1969. Cytogenetic studies of presumptively monozygotic twin girls discordant for gonadal dysgenesis. J. Clin. Endocrinol. Metab., 29: 440–445.CrossRefGoogle ScholarPubMed
Russel, A., Machos, A., Butler, C.J., Abraham, J.M. 1966. Gonadal dysgenesis and its unilateral variant with testis in monozygous twins; related to discordance in sex chromosomal status. J. Clin. Endocrinol. Metab., 26: 1282–1292.CrossRefGoogle Scholar
Scott, J.M., Ferguson-Smith, M.A. 1973. Heterokaryotic monozygotic twins and the acardiac monster. Obst. Gyn. brith., 80: 52–59.CrossRefGoogle Scholar
Shapiro, L.R., Fainsworlh, P.G. 1972. Down's syndrome in twins. Clin. Genet., 3: 364–370.CrossRefGoogle ScholarPubMed
Turpin, R., Lejeune, J., Lafourcade, J., Chigot, P.L., Salmon, C. 1961. Présomption de monozygotisme en dépit d'un dimorphisme sexuel: sujet masculin XY et sujet neutre haplo X. C.R. Acad. Sci. (Paris), 252: 2945–2946.Google Scholar
Turpin, R., Bocquet, L., Grasset, J. 1967. Etude d'un couple monozygote fille normale - monstre acardiaque féminin. Ann. Génét., 10: 107–113.Google Scholar