Hostname: page-component-586b7cd67f-rcrh6 Total loading time: 0 Render date: 2024-11-23T10:45:21.853Z Has data issue: false hasContentIssue false
  • English
  • Français

A Genetic Study of Erythrocyte Arginine-tRNA Synthetase Activity in Man

Published online by Cambridge University Press:  01 August 2014

Sylvia A. McCune ,
P. L. Yu  and
Walter E. Nance
Sylvia A. McCune
Affiliation:
Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA
P. L. Yu
Affiliation:
Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA
Walter E. Nance
Affiliation:
Department of Human Genetics, Medical College of Virginia, Richmond, Virginia, USA

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

To search for evidence of genetic variation among the aminoacyl-tRNA synthetases, a semi-automated assay procedure employing a Technicon Auto Analyzer was used to measure erythrocyte arginine-tRNA synthetase activity in samples obtained from normal human twins of various ages. Variation in enzyme activity within the older DZ twins was five times that of the MZ twins suggesting the existence of genetically determined variation in enzyme activity. Higher enzyme activity was observed in newborn DZ unlike-sexed twins than in like-sexed twins of either zygosity. Possible explanations for this observation are discussed.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 26 , Issue 1 , January 1977 , pp. 21 - 27
Copyright
Copyright © The International Society for Twin Studies 1977

References

REFERENCES

Anderson, W.F. 1969. Evolutionary conservation of the synthetase recognition site of alanine transfer ribonucleic acid. Biochemistry, 8: 3687–3691.Google Scholar
Benirschke, K. 1970. Spontaneous chimerism in mammals - A critical review. Curr. Top. Pathol., 51: 1–61.Google Scholar
Benirschke, K., Kim, C.K. 1973. Multiple pregnancy. N. Engl. J. Med., 288:1276–1284, 1329–1336.Google Scholar
Bick, M.D., Strehler, B.L. 1971. Leucyl transfer RNA synthetase changes during soybean cotyledon senescence. Proc. Natl. Acad. Sci. USA, 68: 224–228.Google Scholar
Busby, W. F., Hele, P. 1970. Estrogen induced variation of lysine tRNA isoacceptors in chicken liver. Biochim. Biophys. Acta, 224: 413–422.Google Scholar
Cameron, A.H. 1968. The Birmingham twin study. Proc. R. Soc. Med., 61: 229–236.Google Scholar
Christian, J.C., Kang, K.W., Norton, J.A. 1974. Choice of estimate of genetic variance from twin data. Am. J. Hum. Genet., 26: 154–161.Google Scholar
El-Alfi, O.S., and Hathout, H. 1969. Maternofetal transfusion: Immunologic and cytogenetic evidence. Am. J. Obstet. Gynecol., 103: 599–600.CrossRefGoogle ScholarPubMed
Elska, A., Matsuka, G., Matiash, V. et al. 1971. tRNA and aminoacyl-tRNA synthetases during differentiation and various functional states of the mammary gland. Biochim. Biophys. Acta, 247: 430–440.Google Scholar
Gallo, R.C., Pestka, S. 1971. Transfer RNA species in normal and leukemic human lymphoblasts. J. Mol. Biol., 52: 195–219.CrossRefGoogle Scholar
Germanyuk, Y., Mironenko, V.I. 1969. Insulin and the attachment of amino acids to the liver transfer RNAs. Nature, 222: 486–487.Google Scholar
Goldman, M., Johnston, W.M., Griffin, A.C. 1969. Comparison of transfer RNA and aminoacyl-tRNA synthetase of liver and ascites tumor cells. Cancer Res., 29: 1051–1055.Google Scholar
Marchin, G.L., Comer, M.M., Neidhardt, F.C. 1972. Viral modifications of the valyl transfer ribonucleic acid synthetase of Escherichia coli . J. Biol. Chem., 247: 5132–5145.Google Scholar
Matthaei, J.H., Schoech, G.K. 1967. Human gene expression I: An aminoacyl-tRNA binding system from human placenta. Biochem. Biophys. Res. Commun., 27: 638–643.Google Scholar
McCune, S.A., 1974. Genetic studies of human aminoacyl-transfer ribonucleic acid synthetases from erythrocytes and placentae of normal twins. Ph.D. thesis, Indiana Univeristy.Google Scholar
Nance, W.E. 1977. The relevance of twin studies in cancer research. In, Mulvihill, J.J. (ed.): The Genetics of Human Cancer (pp. 27–38). New York: Raven Press.Google Scholar
Neth, V.R., Heller, G., Matthaei, H. 1968. Menschliche Protein Synthese III: Preparation von Ribosomen, Transfer-RNA und Aminoacyl-transfer-RNA Synthetase aus Operations-und Biopsie Material. Hoppe-Seyler's, Z. Physiol. Chem., 349: 1514–1524.Google Scholar
Newman, H.H., Freeman, F.N., Holzinger, K. 1937. Twins: Study of Heredity and Environment. Chicago: Univ. Chicago Press.Google Scholar
Ounsted, C., Taylor, D.C. 1972. Gender Differences: Their Ontogeny and Significance. Edinburgh: Churchill Livingstone.Google Scholar
Rennert, Q.M. 1969. Aminoacyl-tRNA synthetase reaction unique to early embryonic tissue of the mouse. Proc. Natl. Acad. Sci. USA, 63: 878–884.CrossRefGoogle ScholarPubMed
Sein, K.T., Becarevic, A., Kanazir, D. 1969. A simple modified method for the extraction of rat liver sRNA. Anal. Biochem., 28: 65–69.Google Scholar
Smith, S.M., Penrose, L.S. 1955. Monozygotic and dizygotic twin diagnosis. Ann. Hum. Genet., 19: 273–289.Google Scholar
Spadafora, C., Igo-Kemenes, T., Zachau, H.G. 1973. Changes in transfer RNA and aminoacyl-tRNA synthetases during sea urchin development. Biochim. Biophys. Acta, 312: 674–684.CrossRefGoogle ScholarPubMed
Strehler, B.L., Hendley, D.D., Hirsch, G.P. 1967. Evidence on a codon restriction hypothesis of cellular differentiation: Multiplicity of mammaHan leucyl-sRNA-specific synthetases and tissue specific deficiency in an alanyl-sRNA synthetase. Proc. Natl. Acad. Sci. USA, 57: 1751–1758.Google Scholar
Tchou, H.P., Claflin, A.J., Muench, K.H. 1971. Tryptophanyl transfer RNA synthetase from lymphocytes of human chronic lymphocytic leukemia. Cancer Res., 31: 679–683.Google Scholar
Warburg, O., Christian, W. 1941. Isolurung and Kristallisation des Garungferments Enolase. Biochem, Z., 310: 384–421.Google Scholar