Hostname: page-component-586b7cd67f-vdxz6 Total loading time: 0 Render date: 2024-11-27T12:03:37.111Z Has data issue: false hasContentIssue false
  • English
  • Français

Gene Interaction in the Phenotypic Expression of Mental Diseases

Published online by Cambridge University Press:  01 August 2014

Lucio Braconi
Lucio Braconi*
Affiliation:
The Gregor Mendel Institute of Medical Genetics and Twin Research, Rome, Italy
*
Istituto Mendel, Piazza Galeno 5, 00161 Roma, Italy

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

A genealogical analysis is carried out on the pedigrees of 10 twin pairs with two or more psychoses. The probands' symptoms reveal some peculiar aspects, i.e., an atypical phenomenology possibly due to the interference of more pathological genes. Schizophrenia, depression, epilepsy, and obsessive neurosis, are found in the pedigrees in different combinations. The study of these pedigrees would lead to the conclusion that interaction of more than one psychosis gives rise to atypical forms as a result of an attempt to establish a state of balance between opposing dynamic actions, as in reversible chemical reactions. Probands' symptoms are less severe and with an often more favourable prognosis. Epilepsy tends to become independent and the major psychoses seem to be epistatic on it. Af for obsessive-compulsive neurosis, probands may progress into schizophrenia or depression if one of these psychoses is present n the pedigree, or may represent the neurotic form of the major disease.

Type
6. Twin Studies in Behavior Genetics
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 25 , Issue 1 , January 1976 , pp. 240 - 243
Copyright
Copyright © The International Society for Twin Studies 1976

References

REFERENCES

Bazzi, T., Matarazzo, F. 1950. Valore diagnostico e significato clinico-nosografico delle sindromi di tipo ossessivo-fobico della schizofrenia. Rass. Neuropsich., 4: 119.Google Scholar
Challiol, V. 1942. Contributo allo studio delle psicosi miste. Arch. Psic. Neur., 1: 20.Google Scholar
Kleist, K., Schwab, H. 1950. Der denkverwritten Schizophrenien. Arch. Psychiat., 184: 28.Google Scholar
Kretschmer, E. 1955. Korperbau und Charakter. Berlin: Springer.Google Scholar
Leonhard, K. 1960. Die atypischen Psychosen und Kleist's Lehre von den endogenen Psychosen. In Grühle, H.: Psychiatric der Gegenwart [Bd. II].Google Scholar
Lo Cascio, G. 1954. Nuove vedute sui confini tra psicastenia c schizofrenia. Law Neurop. 3: 246.Google Scholar
Mitsuda, H. 1967. Clinical Genetics in Psychiatry. Kyoto: Bunko-sha Co.Google Scholar
Pauleikoffff, B. 1957. Atypischen Psychosen. Basel: Karger.Google Scholar
Reda, G., Paretti, E. 1958. Stati ossessivi periodici nel quadro della psicosi depressiva. Riv. Sper. Fen., 82: 7.Google Scholar
Rosenberg, C.M. 1968. Obsessional neurosis. Aust. N. Z. J. Psychiatry, 2: 32.Google Scholar
Sahli, H.L. 1959. Ubergänge manischer-depressive und schizophrener svrläufer. Psych. Neur., 138: 98.Google Scholar
Sakai, T. 1967. Clinico-genetic study on obsessive-compulsive neurosis. In Mitsuda 1967.Google Scholar
Zerbin-Rüdin, E. 1971. Genetische Aspekte der endogenen Psychosen. Fortschr. Neurol. Psychiatr., 39: 9.Google Scholar