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Cytogenetic Observations in Infertile Men Working with Insecticidal Compounds

Published online by Cambridge University Press:  01 August 2014

Fiorella Shabtai ,
Shlomo Bichacho  and
Isaac Halbrecht
Fiorella Shabtai
Affiliation:
B. Gattegno Research Institute of Human Reproduction and Fetal Development, Hasharon Hospital, Petah-Tiqva Tel Aviv University Sackler School of Medicine, Tel Aviv, Israel
Shlomo Bichacho
Affiliation:
B. Gattegno Research Institute of Human Reproduction and Fetal Development, Hasharon Hospital, Petah-Tiqva Tel Aviv University Sackler School of Medicine, Tel Aviv, Israel
Isaac Halbrecht*
Affiliation:
B. Gattegno Research Institute of Human Reproduction and Fetal Development, Hasharon Hospital, Petah-Tiqva Tel Aviv University Sackler School of Medicine, Tel Aviv, Israel
*
B. Gattegno Research Institute of Human Reproduction and Fetal Development, Hasharon Hospital, Petah-Tiqva, Israel

Abstract

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The negative influence of some insecticides on male fertility has been noted. We report our cytogenetic observations on a group of infertile insecticide workers. Increased chromosomal breakage was a constant finding and the Y chromosome was especially damaged. This may account for impaired spermatogenesis. Furthermore, the involvement of heterochromatic chromosomal variants both in the individual susceptibility to the chemically induced damage and in the reproductive fitness is emphasized.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 27 , January 1978 , pp. 51 - 56
Copyright
Copyright © The International Society for Twin Studies 1978

References

REFERENCES

Beechey, C.V. 1973. X-Y chromosome dissociation and sterility in the mouse. Cytogenet. Cell Genet. 12: 60–67.Google Scholar
Bignami, M., Aulicino, F., Velcich, A., Carere, A., Morpurgo, G. 1977. Mutagenic and recombinogenic action of pesticides in Aspergillus nidulans . Mutat. Res. 46: 395–402.Google Scholar
Chandley, A.C., Edmond, P. 1971. Meiotic studies on a subfertile patient with a ring Y chromosome. Cytogenetics 10: 295–304.Google Scholar
Chandley, A.C., MacLean, N., Edmond, P., Fletcher, J., Watson, G.S. 1976. Cytogenetics and infertility in man. II. Testicular histology and meiosis. Ann. Hum. Genet. 40: 165–176.Google Scholar
Cohen, M.M., Dahan, S., Shaham, M. 1975. Cytogenetic evaluation of 500 Jerusalem newborn infants. Isr. J. Med. Sci. 11: 969–977.Google Scholar
Darlington, C.D., Haque, A. 1955. The timing of mitosis and meiosis in Allium aescalonium: a problem of differentiation. Heredity 9: 117–127.CrossRefGoogle Scholar
Guerzoni, M.E., Del Cupolo, L. 1976. Attività mutagenica degli antiparassitari. Riv. Sci. Tecn. Nutr. Um. 6: 161–165.Google Scholar
Hultén, M., Eliasson, R., Tillinger, K.G. 1970. Low chiasma count and other meiotic irregularities in two infertile 46,XY men with spermatogenic arrest. Hereditas 65: 285–290.CrossRefGoogle Scholar
Jacobs, P.A., Frackiewicz, A., Law, P., Hilditch, C.J., Morton, N.E. 1975. The effect of structural aberrations of the chromosomes on reproductive fitness in man. II. Results. Clin. Genet. 8: 169–178.CrossRefGoogle ScholarPubMed
Kunze, J., Mau, G. 1975. Ax and C9 marker chromomes in children with combined minor and major malformations. Lancet i: 273.Google Scholar
Mcllree, M.E., Price, W.H., Court Brown, W.M., Selby-Tulloch, W., Newsam, J.E., McLean, N. 1966. Chromosome studies on testicular cells from 50 subfertile men. Lancet ii: 69–71.CrossRefGoogle Scholar
Meist, H. 1975. Clastogenic effect of TrenimonR on in vitro chromosomes of phenotypically healthy subjects with morphologically abnormal karyotype. Acta Genet. Med. Gemellol. 24: 269–282.Google Scholar
Miklos, G.L.G. 1974. Sex-chromosome pairing and male fertility. Cytogenet. Cell Genet. 13: 558–577.CrossRefGoogle ScholarPubMed
Natarajan, A.T., Tates, A.D. (in press). A correlative study on cytogenetic damage induced by chemical mutagens in bone marrow and spermatogonia of mice. II. Mitomycin C. Mutat. Res. Google Scholar
Pearson, P.L., Ellis, J.D., Evans, H.J. 1970. A gross reduction in chiasma formation during meiotic prophase and a defective DNA repair mechanism associated with a case of human male infertility. Cytogenetics 9: 460–467.CrossRefGoogle Scholar
Rees, H. 1952. Asynapsis and spontaneous chromosome breakage in Scilla . Heredity 6: 89–97.CrossRefGoogle Scholar
Seabright, M. 1971. Rapid banding technique for human chromosomes. Lancet ii: 971–972.CrossRefGoogle Scholar
Seabright, M. 1976. Patterns of induced aberrations in humans with abnormal autosome complements. In Pearson, P.L. and Lewis, K.R. (eds.): Chromosomes today (Vol. V, pp. 293–298). New York, John Wiley.Google Scholar
Sperling, K., Kaden, R. 1971. Meiotic studies of the ejaculated seminal fluid of humans with normal sperm count and oligospermia. Nature (Lond) 232: 481.Google Scholar
Sumner, A.T. 1972. A simple technique for demonstrating centromeric heterochromatin. Exp. Cell Res. 75: 304–306.CrossRefGoogle ScholarPubMed
Tates, A.D., Natarajan, A.T. 1976. A correlative study on the genetic damage induced by chemical mutagens in bone marrow and spermatogonia of mice. I. CNU-ethanol. Mutat. Res. 37: 267–277.CrossRefGoogle Scholar
Shabtai, F., Bichacho, S., Halbrecht, I. 1977. Cytogenetics of male infertility. Abstracts of the Second International Congress of Human Reproduction. Tel-Aviv, Israel, 10 23–28 1977, p. 90.Google Scholar
Van Buul, P.P. 1976. A comparative study of the frequencies of radiation-induced chromosome aberrations in somatic and germ cells of the Rhesus monkey (Macaca mulatta). Mutat. Res. 36: 223–236.Google Scholar
Whorton, D., Krauss, R.M., Marshall, S., Milby, T.H. 1977. Infertility in male pesticide workers. Lancet ii: 1259–1261.CrossRefGoogle Scholar